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Microphysio24: From organoids to organs-on-chips

Colloques et congés, Event, News, slider home6 May 2024
Microphysio24: From organoids to organs-on-chips The 2nd edition of the MicroPhysio conference on "Micro-physiological models: From organoids to organs-on-chip"  will take place at the CNRS center in Cargèse (www.iesc.univ-corse.fr) from September 23rd to September 27th, 2024. It is becoming increasingly clear that even the best in vivo models such as genetically-modified mouse models or orthotopic patient-derived xenografts cannot recapitulate the full complexity of human…

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ImagoSeine – CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

Home publis, News3 May 2024
The ImagoSeine platform contributed to the publication of a new article in Circulation: CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT   Abstract: BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions…

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Dumont Lab – Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane

Home publis, News3 May 2024
The Dumont Lab contributed to the publication of a new article in Molecular Biology of Cell: Germ fate determinants protect germ precursor cell division by reducing septin and anillin levels at the cell division plane   Abstract: Animal cell cytokinesis, or the physical division of one cell into two, is thought to be driven by constriction of an…

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Ribes Lab – Non-Mammalian Models for Understanding Neurological Defects in RASopathies

Home publis, News29 April 2024
The Ribes Lab contributed to the publication of a review in Biomedicines: Non-Mammalian Models for Understanding Neurological Defects in RASopathies   Abstract: RASopathies, a group of neurodevelopmental congenital disorders stemming from mutations in the RAS/MAPK pathway, present a unique opportunity to delve into the intricacies of complex neurological disorders. Afflicting approximately one in a thousand newborns, RASopathies manifest…

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Jackson/Verbavatz Lab – Staying on track – Keeping things running in a high-end scientific imaging core facility

Home publis, News26 April 2024
The  Jackson/Verbavatz Lab contributed to the publication of a themed issue article: Staying on track – Keeping things running in a high-end scientific imaging core facility   Abstract: Modern life science research is a collaborative effort. Few research groups can single-handedly support the necessary equipment, expertise and personnel needed for the ever-expanding portfolio of technologies that are required…

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Raote Lab – TANGO1 inhibitors reduce collagen secretion and limit tissue scarring

Home publis, News26 April 2024
The Raote Lab published a new article in Nature communications: TANGO1 inhibitors reduce collagen secretion and limit tissue scarring   Abstract: Uncontrolled secretion of ECM proteins, such as collagen, can lead to excessive scarring and fibrosis and compromise tissue function. Despite the widespread occurrence of fibrotic diseases and scarring, effective therapies are lacking. A promising approach would be…

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IJM Seminars – Christophe Leterrier – 31/05/2024

Event, IJM Séminars, LECTURES AND CONGRESSES, News22 April 2024
Invited by the Ladoux/Mège Lab, Christophe Leterrier (Aix Marseille Université, CNRS, INP, NeuroCyto Lab) will present an IJM seminars on the theme: The axonal cytoskeleton down to the nanoscale   Abstract: The intricate arborization and molecular identity of axons is maintained for decades, but must also continuously adapt to changes in the environment and modulate the activity of…

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Duharcourt Lab – Small-RNA-guided histone modifications and somatic genome elimination in ciliates

Home publis, News16 April 2024
The Duharcourt Lab published a new review in WIREs RNA : Small-RNA-guided histone modifications and somatic genome elimination in ciliates   Abstract: Transposable elements and other repeats are repressed by small-RNA-guided histone modifications in fungi, plants and animals. The specificity of silencing is achieved through base-pairing of small RNAs corresponding to the these genomic loci to nascent noncoding…

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Conduit Lab – γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila

Home publis, News15 April 2024
The Conduit Lab published a new article in Journal of Cell Science: γ-TuRCs and Augmin are required for the development of highly branched dendritic arbors in Drosophila   Abstract: Microtubules are nucleated by γ-tubulin ring complexes (γ-TuRCs) and are essential for neuronal development. Nevertheless, γ-TuRC depletion has been reported to perturb only higher-order branching in elaborated Drosophila larval class IV…

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