The Palancade Lab and the ProteoSeine platform contributed to the publication of a new article in PLOS genetics: Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract: Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome instability.…

The Courtier Lab published a new article in Development: Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process Abstract: Left-right asymmetries have repeatedly evolved in diverse animals and affect the position, shape or size of specific organs. How novel left-right asymmetries arise remains unknown. Here, we examined Drosophila pachea, where males…

The Raote Lab contributes to the publication of a new article in Nature communications: TUG protein acts through a disordered region to organize the early secretory pathway Abstract: The Endoplasmic Reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a network of tubules and vesicles known for producing COPI vesicles and receiving COPII vesicles from the ER. Much about its…

The Palancade Lab and the ProtéoSeine platform contributed to the publication of a new article in PLOS Genetics: Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract: Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome instability.…

The Guichet Lab contributed to a new article published in Journal of Evolutionary Biology: Sheltered load in fungal mating-type chromosomes revealed by fitness experiments Abstract: Sex chromosomes and mating-type chromosomes can carry large regions with suppressed recombination. As a result of a lower efficacy of selection, recessive deleterious mutations are expected to accumulate in these non-recombining regions.…

The Greenberg lab contributed to a new publication in Epigenetics: PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Abstract: Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions (DMRs). These show a…

The Ladoux-Mège team, the MSC laboratory, and the Cochin Institute have collaborated on a new article published in Biophysical Journal: The enteric nervous system is 10 times stiffer than the brain The intestine is the only organ in our body with a quasi-autonomous innervation, the enteric nervous system, commonly referred to as the “second brain.” The…

The Romet-Lemonne/Jégou Lab published a new publication in PNAS: Continuous self-repair protects vimentin intermediate filaments from fragmentation Abstract: Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening, and subunit…

The Ladoux/Mège Lab contributed to the publication of a new article in The European Physical Journal E: Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Abstract: Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects tissue…

The Minc Lab published a new article in Current Biology: Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot   Abstract: Early embryos undergo rounds of division, producing cells of reducing sizes that must scale the distance chromosomes segregate. A new study shows that this scaling results from a cell-size-dependent dampening of cytoplasmic flows that advect…