The Ladoux/Mege published a new article in Nature Physics: Dynamic forces shape the survival fate of eliminated cells   Abstract: Tissues eliminate unfit, unwanted or unnecessary cells through cell extrusion, and this can lead to the elimination of both apoptotic and live cells. However, the mechanical signatures that influence the fate of extruding cells remain unknown. Here we…

The Gazave Lab published a new article in Molecular Biology and Evolution: The Rich Evolutionary History of the Reactive Oxygen Species Metabolic Arsenal Shapes Its Mechanistic Plasticity at the Onset of Metazoan Regeneration   Abstract Regeneration, the ability to restore body parts after injury, is widespread in metazoans; however, the underlying molecular and cellular mechanisms involved in this…

The ProtéoSeine platform and the Léon Lab published a new publication in BMC Microbiology: Candida albicans cells exhibit media specific proteomic profiles during induction of filamentation Abstract: Candida albicans is an opportunist pathogen responsible for a broad spectrum of infections, from superficial mycosis to the systemic disease candidiasis. C. albicans has various morphological forms, including unicellular budding yeasts, filamentous pseudohyphae…

The Grange / Geigl Lab published a new article in Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Sheep were one of the first animals to be domesticated. The analysis of genomes retrieved from archaeological sheep bones preserved in Neolithic sites allowed Kaptan and colleagues to demonstrate that present-day sheep descend from Anatolian wild…

The Minc Lab contributed to the publication of a new article in Biophysical Journal : A physical model for M1-mediated influenza A virus assembly   Abstract: Influenza A virus particles assemble at the plasma membrane of infected cells. During assembly all components of the virus come together in a coordinated manner to deform the membrane into a…

The Duharcourt Lab published a new article in Nucleic Acids Research: The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium   Abstract: Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the development of the somatic nucleus. Twenty-five nucleotide scanRNAs (scnRNAs) are produced from the entire…

The Romet-Lemonne/Jégou Lab contributed a new article published in PNAS: HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1   Abstract: Many enveloped viruses bud from the plasma membrane that is tightly associated with a dense and thick actin cortex. This actin network represents a significant challenge for membrane deformation and scission, and how it is remodeled…