The Prioleau publisehd a new article in Nucleic Acid Research: Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus   Abstract: Les génomes des vertébrés se dupliquent en activant des dizaines de milliers d'origines de réplication de l'ADN, réparties de manière irrégulière le long du génome. Cependant, en l'absence d'une séquence…

The Doye Lab published a new article in Current Opinion in Cell Biology : Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket   Résumé: Nuclear pore complexes (NPCs) are giant molecular assemblies that form the gateway between the nucleus and the cytoplasm and accommodate the bidirectional transport of a large variety of…

The Protéoseine platform contributed to the publication of an article in Journal of Proteome Research: Molecular Mechanisms of Acanthamoeba castellanii Response to Different Sources of Oxidative Stress   Abstract: Oxidative stress is a biological principle affecting all life on Earth and is also an important factor in the pathogen-host relationship. The pathogenic free-living amoeba Acanthamoeba castellanii has several pathways to cope…

The Gazave Lab contributed to the publication of a new article in Science Advances: A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian   Abstract: The fertile gonad includes cells of two distinct developmental origins: the somatic mesoderm and the germ line. How somatic and germ cells interact to develop…

The Minc lab and Dumont lab published a report in Current Biology: Cell shape modulates mitotic spindle positioning forces via intracellular hydrodynamics   Abstract: The regulation of mitotic spindle positioning and orientation is central to the morphogenesis of developing embryos and tissues.1 ,2 ,3 ,4 ,5  In many multicellular contexts, cell geometry…

The Ladoux/Mege published a new article in Nature Physics: Dynamic forces shape the survival fate of eliminated cells   Abstract: Tissues eliminate unfit, unwanted or unnecessary cells through cell extrusion, and this can lead to the elimination of both apoptotic and live cells. However, the mechanical signatures that influence the fate of extruding cells remain unknown. Here we…

The Gazave Lab published a new article in Molecular Biology and Evolution: The Rich Evolutionary History of the Reactive Oxygen Species Metabolic Arsenal Shapes Its Mechanistic Plasticity at the Onset of Metazoan Regeneration   Abstract Regeneration, the ability to restore body parts after injury, is widespread in metazoans; however, the underlying molecular and cellular mechanisms involved in this…