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DECODERS platform: decoding locus-specific molecular interaction networks

 

Supported by the Transverse program of the LabEx (Laboratory of Excellence) Who Am I?, the DECODERS platform (established in November 2021) aims to develop and propose innovative proteomic and transcriptomic approaches within a consortium of laboratories gathered around a common scientific question: how do loci-specific molecular interactions networks participate in cellular identity and plasticity?

In this context, the DECODERS project aims to combine in situ proximity biotinylation and loci-specific targeting techniques to identify the molecular components (proteins or RNAs) of individual genomic regions, through mass spectrometry or high-throughput sequencing.

The projects includes scientific monitoring and methodological developments to recommend and make available the latest proximity biotinylation technologies.

Keywords: In situ Proximity-dependent Biotinylation (BioID), APEX2/TurboID, Proteomic, Transcriptomic, CRISPR/dCas9, HYPRO, AMAPEX

 Contact   Bâtiment Buffon, 3th floor, room 354B