The Veitia Lab published a new article in Journal of inherited metabolic disease: Gene Dosage Sensitivity and Human Genetic Diseases Abstract: Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a normal phenotype…

The Romet-Lemonne/Jégou lab contributed to the publication of a new article in médecine/science: Caveolin-1 stiffens the plasma membrane and limits transcellular tunnel expansion Lemichez E, Morel C, Leduc C, Bassereau P. La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires [Caveolin-1 stiffens the plasma membrane and limits transcellular tunnel expansion]. Med Sci (Paris).…

The Ladoux/Mege Lab contributed to the publication of a new article in Nature Communications: A multicellular star-shaped actin network underpins epithelial organization and connectivity Abstract: Epithelial tissues withstand external stresses while maintaining structural stability. Bicellular junctions and the actomyosin network support epithelial integrity, packing and remodelling. While their role in development and disease are well studied, their…

The ProteoSeine platform contributed to the publication of a new article in Journal of biological chemistry: Structural and functional characterization of CREB-binding protein (CREBBP) as a histone propionyltransferase Abstract: In addition to histone acetylation, histone lysine propionylation (such as the H3K18Pr mark) has recently attracted significant attention as a common and abundant modification linking the cellular metabolic…

The Palancade Lab and the ProteoSeine platform contributed to the publication of a new article in PLOS genetics: Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract: Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome instability.…

The Courtier Lab published a new article in Development: Evolution of a novel left-right asymmetry in organ size by co-option of a tissue rotation process Abstract: Left-right asymmetries have repeatedly evolved in diverse animals and affect the position, shape or size of specific organs. How novel left-right asymmetries arise remains unknown. Here, we examined Drosophila pachea, where males…

The Raote Lab contributes to the publication of a new article in Nature communications: TUG protein acts through a disordered region to organize the early secretory pathway Abstract: The Endoplasmic Reticulum (ER)-Golgi Intermediate Compartment (ERGIC) is a network of tubules and vesicles known for producing COPI vesicles and receiving COPII vesicles from the ER. Much about its…

The Palancade Lab and the ProtéoSeine platform contributed to the publication of a new article in PLOS Genetics: Cellular imbalance of specific RNA binding proteins associates with harmful R-loops Abstract: Understanding how the assembly of nascent mRNA into a ribonucleoprotein (mRNP) influences R-loop homeostasis is crucial for gaining insight into the cellular mechanisms that prevent genome instability.…

The Guichet Lab contributed to a new article published in Journal of Evolutionary Biology: Sheltered load in fungal mating-type chromosomes revealed by fitness experiments Abstract: Sex chromosomes and mating-type chromosomes can carry large regions with suppressed recombination. As a result of a lower efficacy of selection, recessive deleterious mutations are expected to accumulate in these non-recombining regions.…

The Greenberg lab contributed to a new publication in Epigenetics: PIK3R1 and G0S2 are human placenta-specific imprinted genes associated with germline-inherited maternal DNA methylation   Abstract: Genomic imprinting is the parent-of-origin specific monoallelic expression of genes that result from complex epigenetic interactions. It is often achieved by monoallelic 5-methylcytosine, resulting in the formation of differentially methylated regions (DMRs). These show a…