The Ladoux/Mege Lab published a new article dans PNAS: Flocking and giant fluctuations in epithelial active solids   Significance During embryonic development and wound healing, epithelial cells usually display in-plane polarity over large spatial scales and move coherently. However, most in vitro studies have examined the fluid-like chaotic dynamics of epithelial cells, in which collective cellular flows…

The Wassmann Lab published a new article in Current Biology: Prolonged metaphase II arrest weakens Aurora B/C-dependent error correction in mouse oocytes   Abstract: Segregation errors in meiosis lead to aneuploid gametes and consequently to the development of trisomies, spontaneous abortion and fertility issues. Chromosome attachment to the microtubules of the bipolar spindle is a prerequisite for…

The Doye Lab contributed to the publication of a new article in Nature cell biology: Nuclear pores safeguard the integrity of the nuclear envelope   Abstract: Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange, which is essential for eukaryotes. Mutations in the central scaffolding components of NPCs are associated with genetic diseases, but how they manifest only in specific…

The Ribes/Nedelec Lab contribued to the publication of a new article in Nature Communications: A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification   Abstract: Studying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies. Here, we use pluripotent…

The Palancade contribued to the publication of a new article in Nature communications: A bifunctional snoRNA with separable activities in guiding rRNA 2’-O-methylation and scaffolding gametogenesis effectors Abstract: Small nucleolar RNAs are non-coding transcripts that guide chemical modifications of RNA substrates and modulate gene expression at the epigenetic and post-transcriptional levels. However, the extent of their…

The Romet-Lemonne / Jégou Lab contributed to the publication of a new article in Cell: Genetically encoded reporters of actin filament organization in living cells and tissues   Abstract: The cytoskeletal protein actin is crucial for cell shape and integrity throughout eukaryotes. Actin filaments perform essential biological functions, including muscle contraction, cell division, and tissue morphogenesis. These diverse…

The Ladoux/Mège published a new article in Nature material: Force transmission is a master regulator of mechanical cell competition Abstract: Cell competition is a tissue surveillance mechanism for eliminating unwanted cells, being indispensable in development, infection and tumourigenesis. Although studies have established the role of biochemical mechanisms in this process, due to challenges in measuring forces in…

The Veitia Lab published a new review in Trends in biochemical sciences: Rethinking transcription factor dynamics and transcription regulation in eukaryotes Abstract: Transcription factors (TFs) control gene expression by binding to specific DNA motifs in cis-regulatory elements. Cooperativity has been thought to ensure TF binding specificity. Recent research suggests that, at least in yeast, the role of cooperativity…

The Romet-Lemonne/Jégou lab contributed to the publication of a new article in Nature communications : Histidine 73 methylation coordinates β-actin plasticity in response to key environmental factors Abstract: The functional importance of the methylation of histidine 73 (H73) in actin remains unclear. Focusing on cytoplasmic β-actin, present in all mammalian cells, we use molecular dynamics simulations with a polarizable…

The Palancade Lab published a new article in Nature Communications: DNA lesions can frequently precede DNA:RNA hybrid accumulation   Abstract: While DNA:RNA hybrids contribute to multiple genomic transactions, their unscheduled formation is a recognized source of DNA lesions. Here, through a suite of systematic screens, we rather observed that a wide range of yeast mutant situations primarily triggering DNA…