The Wassmann Lab published a new article in EMBO Reports: Oocyte selection: a tale of individualism, dominance and sacrifice Abstract: Oocyte development is a fierce competitive process in which only a small fraction of germ cells survives massive waves of cell death to become a fertilizable egg. Using an ex vivo 4D imaging system, Zhang and…

The Borghi Lab contributed to the publication of a new article in Microbiological Research: Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion Abstract: Chlamydia trachomatis (Ct), a Gram-negative obligate intracellular pathogen, manipulates host actin dynamics to facilitate its entry, development, and exit. It assembles a dynamic actin cage around its intracellular niche,…

The Borghi lab contributed to the publication of a new article in Nature communications: Meningococci drive host membrane tubulation to recruit their signaling receptors Abstract: Once passed into the bloodstream, bacterial pathogens have a limited time to interact with permissive receptors at the surface of host cells. Neisseria meningitidis has developed an extremely effective strategy allowing it to find…

The Pintard Lab published a new article in The Journal of Cell biology: Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Abstract: Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood. Using Caenorhabditiselegans Katanin, which…

The Veitia Lab published a new article in Molecular & Cellular Proteomics: : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Abstract: Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study aims…

The Ladoux/Mège Lab published a new nouvel article PNAS: Regulation of epithelial tissue homeostasis by active transepithelial transport Abstract: Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of osmotic and…

The Ladoux/Mege et Jackson/Verbavatz published a new article "news and views" in Nature : ‘Memory foam’ skeleton in cells helps them to navigate d'Alessandro J, Heuzé ML. 'Memory foam' skeleton in cells helps them to navigate. Nature. 2025 Nov;647(8088):42-44. doi: 10.1038/d41586-025-03448-z. PMID: 41184472.

The Ribes / Nedelec Lab published a new article in PLOS Biology: Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Abstract: Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and genetically modulating…

The Dumont Lab published a new article in Journal of Cell Biology: Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation The Minc Lab also contributed to this article. Abstract: Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and anaphase B, in which the anaphase…

The ProtéoSeine platform contributed to the publication of a new article in Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Abstract: The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify…