L'équipe Ladoux/Mège a publié un nouvel article dans Science Advances:  Cytoplasmic crowding drives intracellular viscoelastic increase during epithelial maturation Résumé : The cytoplasm is a crowded, active medium whose mechanical properties underpin essential cellular functions, yet how intracellular rheology adapts during tissue maturation remains unclear. Here, we examine the evolution of cytoplasmic viscoelasticity in Madin-Darby canine…

La plateforme ProtéoSeine a contribué à un nouvel article publié dans Journal of Hazardous Material : CBP inhibition and histone H3K18 hypoacetylation induced by the hematotoxic benzene metabolite 1,4-benzoquinone   Résumé : Benzene (BZ) is a pervasive environmental and occupational carcinogen whose leukemogenicity depends on metabolic activation into reactive intermediates, notably 1,4-benzoquinone (BQ). While genotoxic effects such as…

L'équipe Gazave a publié un éditorial dans BMC Biology : The brilliant future of non-traditional model organisms in biology Gazave E, Hampl V, E Podrabsky J, Whitworth D. The brilliant future of non-traditional model organisms in biology. BMC Biol. 2026 Oct 26;24(1):224. doi: 10.1186/s12915-026-02770-w. PMID: 42934738; PMCID: PMC13700528.  

L'équipe Veitia a publié un article dans Advanced Biology : AND Gates as Sources of Biological Nonlinearity: Relevance to Genetic Dominance Résumé : AND-gating is a mechanism capable of generating nonlinear biological responses because a productive output requires the joint satisfaction of several necessary molecular events. AND gates are considered here in the context of gene expression.…

L'équipe Minc a publié un nouvel article dans Biophysical Journal : Mechanical properties of chiral helical polymers: From single filaments to actin bundles Résumé : The mechanical properties of biological polymers are essential to their biological functions. Here, we introduce a highly coarse-grained model of helical filaments that preserves helicity and chirality while enabling mesoscale simulations.…

L'équipe Gazave a publié un nouvel article dans Cellular and Molecular Life Sciences : Understanding ROS signaling and evolution during animal regeneration offers promising opportunities for novel therapeutic approaches Résumé : Despite their potentially harmful oxidative properties, Reactive Oxygen Species (ROS) have been harnessed by living organisms during evolution as signaling molecules involved in various physiological processes.…

L'équipe Gazave a publié un nouvel article dans British Journal for the Philosophy of Science : The Identity of Stem Cell Kinds Résumé : Stem cells are defined by their self-renewal and differentiation abilities. Through those properties, they ensure the production and renewal of organisms’ cells and, in some species, the regeneration of lost parts, making them…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans FASEB Journal : Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth Résumé : Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including…

L'équipe Conduit a publié un nouvel article dans Journal of Cell Biology : A structural model for the autoinhibition of the γ-TuRC–activating CM1 domain Résumé : Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved centrosomin motif 1…

L'équipe Ladoux/Mège a publié un nouvel article dans Nature Communications : A principal-stress rule for cell division in epithelia Résumé : Dense active materials must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, where, according to Hertwig’s century-old rule, cells…