L'Institut Jacques Monod (IJM), unité mixte de recherche du CNRS et de l'université Paris Diderot, est l'un des principaux pôles de recherche fondamentale en biologie de la région parisienne.
Son directeur est Michel Werner, directeur de recherche.
Menu/Languages.html
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Actualités de l'IJM
Mars 2019 : Le contrôle temporel de la réplication de l’ADN est-il constant tout au long de la phase S ?
Avant chaque division cellulaire, le génome complet de la cellule doit être entièrement et fidèlement dupliqué pour que l’intégralité de l’information génétique soit transmise à chacune des cellules filles. Cette duplication s’effectue selon un programme de réplication complexe pendant la relativement brève phase de synthèse (phase S). La réplication démarre en de multiples sites du génome appelés origines de réplication. Ces sites sont au nombre de dizaines de milliers dans les génomes de vertébrés. Leur déclenchement est organisé dans le temps. Ainsi certaines régions sont répliquées en début, milieu ou fin de phase S. Le contrôle du moment de réplication de ces régions est très conservé dans l’ensemble des cellules d’une population. A ce jour, les mécanismes et les facteurs moléculaires responsables de l’établissement de ce contrôle restent très peu connus. Les chercheurs de l’équipe de Marie-Noëlle Prioleau se sont intéressés à évaluer le degré de variabilité de ce programme temporel pour identifier les mécanismes potentiels impliqués dans cette régulation.
Janvier 2019 : quand Transcription rencontre Réplication
Comment les cellules font-elles face à leurs propres contradictions? Pour assurer l'expression, le maintien et la propagation de son génome, la cellule doit mettre en place des activités enzymatiques potentiellement conflictuelles, la transcription et la réplication. Dans un article récemment publié dans la revue eLife, les chercheurs de l’équipe Libri montrent, chez la levure S. cerevisiae, que les facteurs de réplication se liant à l'ADN pour définir les endroits d'où la réplication est initiée, "protègent" également ces sites de la transcription avoisinante, qu'ils terminent. Et que les niveaux faibles de transcription qui néanmoins envahissent ces sites, influencent l'activité de réplication.
Janvier 2019 : Adaptation de la forme cellulaire à la géométrie de son environnement pour migrer.
La migration cellulaire est un mécanisme primordial qui assure des fonctions essentielles telles que la mise en place des tissus et des organes au cours du développement ou encore la cicatrisation des tissus endommagés.
Emplois et stages
L'Institut Jacques Monod recrute !
Février 2019 : CDD 6 mois, plateforme imagoSeine, Microscopie photonique.
Les prochains événements
- vendredi24 mai2019
Séminaire de l'Institut
Atef ASNACIOS
Interplay between single-cell mechanics and functions - lundi27 mai2019
Habilitation à diriger des recherches
Serge DMITRIEFF
Discrete and continuous models of intra-cellular mechanics - mardi28 mai2019
Séminaire de l'Institut
Pr Rodney ROTHSTEIN
The building yeast RNR regulator, Sm11, is an ortholog of Mis18 and plays a dNTP-independent role in chromosome segregation