The Ladoux/Mège lab published a new article in Science Advances:  Cytoplasmic crowding drives intracellular viscoelastic increase during epithelial maturation Abstract: The cytoplasm is a crowded, active medium whose mechanical properties underpin essential cellular functions, yet how intracellular rheology adapts during tissue maturation remains unclear. Here, we examine the evolution of cytoplasmic viscoelasticity in Madin-Darby canine kidney…

The ProtéoSeine lab contributed to a new article published in Journal of Hazardous Material: CBP inhibition and histone H3K18 hypoacetylation induced by the hematotoxic benzene metabolite 1,4-benzoquinone   Abstract: Benzene (BZ) is a pervasive environmental and occupational carcinogen whose leukemogenicity depends on metabolic activation into reactive intermediates, notably 1,4-benzoquinone (BQ). While genotoxic effects such as DNA damage and…

The Gazave Lab published an éditorial in BMC Biology: The brilliant future of non-traditional model organisms in biology Gazave E, Hampl V, E Podrabsky J, Whitworth D. The brilliant future of non-traditional model organisms in biology. BMC Biol. 2026 Oct 26;24(1):224. doi: 10.1186/s12915-026-02770-w. PMID: 42934738; PMCID: PMC13700528.  

The Veitia Lab published a new article in Advanced Biology: AND Gates as Sources of Biological Nonlinearity: Relevance to Genetic Dominance Abstract: AND-gating is a mechanism capable of generating nonlinear biological responses because a productive output requires the joint satisfaction of several necessary molecular events. AND gates are considered here in the context of gene expression. Three…

The Minc lab published a new article in Biophysical Journal: Mechanical properties of chiral helical polymers: From single filaments to actin bundles Abstract: The mechanical properties of biological polymers are essential to their biological functions. Here, we introduce a highly coarse-grained model of helical filaments that preserves helicity and chirality while enabling mesoscale simulations. This is…

The Gazave lab published a new article in Cellular and Molecular Life Sciences: Understanding ROS signaling and evolution during animal regeneration offers promising opportunities for novel therapeutic approaches Abstract: Despite their potentially harmful oxidative properties, Reactive Oxygen Species (ROS) have been harnessed by living organisms during evolution as signaling molecules involved in various physiological processes. In the…

The Gazave lab published a new publication in British Journal for the Philosophy of Science: The Identity of Stem Cell Kinds Abstract: Stem cells are defined by their self-renewal and differentiation abilities. Through those properties, they ensure the production and renewal of organisms’ cells and, in some species, the regeneration of lost parts, making them a key…

The ProtéoSeine platform contributed to the publication of a new article in FASEB Journal: Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth Abtract: Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including ERβ1, ERβ2,…

The Conduit a published a new article in Journal of Cell Biology: A structural model for the autoinhibition of the γ-TuRC–activating CM1 domain Abstract: Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved centrosomin motif 1 (CM1) domain,…

The Ladoux/Mège published a new article in Nature Communications: A principal-stress rule for cell division in epithelia Abstract: Dense active materials must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, where, according to Hertwig’s century-old rule, cells divide along their…