The Gazave lab published a new article in Cellular and Molecular Life Sciences: Understanding ROS signaling and evolution during animal regeneration offers promising opportunities for novel therapeutic approaches Abstract: Despite their potentially harmful oxidative properties, Reactive Oxygen Species (ROS) have been harnessed by living organisms during evolution as signaling molecules involved in various physiological processes. In the…

The Gazave lab published a new publication in British Journal for the Philosophy of Science: The Identity of Stem Cell Kinds Abstract: Stem cells are defined by their self-renewal and differentiation abilities. Through those properties, they ensure the production and renewal of organisms’ cells and, in some species, the regeneration of lost parts, making them a key…

The ProtéoSeine platform contributed to the publication of a new article in FASEB Journal: Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra-Nuclear Signaling to Modulate Human Granulosa Cell Growth Abtract: Estradiol (E2) regulates ovarian follicular development and granulosa cell (GC) function primarily through estrogen receptor β (ERβ). Human GCs express several ERβ isoforms, including ERβ1, ERβ2,…

The Conduit a published a new article in Journal of Cell Biology: A structural model for the autoinhibition of the γ-TuRC–activating CM1 domain Abstract: Microtubule nucleation by γ-tubulin ring complexes (γ-TuRCs) must be spatiotemporally controlled to avoid major cell division errors. γ-TuRCs are activated by the centrosome-specific binding of a highly conserved centrosomin motif 1 (CM1) domain,…

The Ladoux/Mège published a new article in Nature Communications: A principal-stress rule for cell division in epithelia Abstract: Dense active materials must continuously relieve internal mechanical stress to remain structurally stable as they are driven far from equilibrium. In epithelial tissues, this relief occurs through cell division, where, according to Hertwig’s century-old rule, cells divide along their…

The Bonazzi Lab published a new article in Nature Communications: Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up Abstract: Bacterial proliferation in confined spaces occurs in biofilms, intracellular compartments, or infection sites, generating mechanical constraints. We investigated how growth-induced mechanical pressure affects bacterial physiology using a microfluidic device ensuring nutrient access. We found…

The Ladoux/Mège Lab published a new article in Nature Communications: Extracellular-matrix mediated stresses spatially bias myoblast fusion and myotube growth Abstract: Myoblast fusion into multinucleated myotubes is essential for skeletal muscle development and repair, yet how tissue-scale mechanics contributes to this process remains poorly understood. Here, we show that primary myoblasts behave as an evolving active nematic…

The  Duharcourt lab published a review in Nature Reviews Genetics: The mechanistic and evolutionary diversity of programmed DNA elimination Abstract: Beyond somatic mutations, the genetic makeup of an organism is often assumed to remain constant across all cells or nuclei within individuals. However, some organisms exhibit programmed DNA elimination (PDE), whereby specific cell lineages lose DNA segments…

The Veitia lab published a new article in FASEB Journal: Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back. Abstract: Many developmental and physiological outcomes depend on transcriptional thresholds or switches. The transcriptional output, ultimately measured as mature RNA, is determined by a series of molecular steps that can introduce thresholds, bottlenecks, or…

The Prioleau Lab published a new article in The FEBS Journal: Ploidy-dependent modulation of DNA replication kinetics in Xenopus Abstract: An important question in cell biology is how DNA replication programs scale with genome size following polyploidization, an evolutionary process that increases DNA content without proportionally extending the cell cycle duration. In particular, comparative analyses across…