The Ribes / Nedelec Lab published a new article in PLOS Biology: Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Abstract: Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and genetically modulating…

The Dumont Lab published a new article in Journal of Cell Biology: Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation The Minc Lab also contributed to this article. Abstract: Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and anaphase B, in which the anaphase…

The ProtéoSeine platform contributed to the publication of a new article in Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Abstract: The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify…

The Duharcourt Lab published a new article in Nucleic Acids Research: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium The Institut Jacques Monod's ProtéoSeine platform contributed to this article. Abstract: To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs,…

The Borghi Lab published a new article in PLoS Computational Biology: Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy   Abstract: Segmentation and detection of biological objects in fluorescence microscopy is of paramount importance in cell imaging. Deep learning approaches have recently shown promise to advance, automatize and accelerate analysis. However, most of the interest…

The Léon Lab published, in collaboration with the  ProtéoSeine platform, a new article in Plos Genetics: A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition   Abstract: The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose repression pathway,…

The ImagoSeine plaftorm contributed to the publication of a new article in Communication Biology: Myocardial disarray drives metabolic inefficiency in human cardiomyocytes   Abstract: Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular morphology. Despite the…

The Raote Lab contributed to the publication of a new article in Nature reviews molecular cell biology: Towards a unified framework for the function of endoplasmic reticulum exit sites Résumé: Endoplasmic reticulum exit sites (ERES) are specialized, ribosome-free ER subdomains that serve as dynamic portals for COPII-mediated export of proteins from the ER. Beyond their role…

The ProtéoSeine platform contributed to the publication of a new article in Cell Host & Microbe: Immunometabolic reprogramming of macrophages by gut microbiota-derived cadaverine controls colon inflammation   Abstract: Cadaverine is a polyamine produced by the gut microbiota with links to health and disease, notably inflammatory bowel disease (IBD). Here, we show that cadaverine shapes monocyte-macrophage immunometabolism…

The Greenberg Lab published a new review in Plos Genetics: Epigenetic relay: Polycomb-directed DNA methylation in mammalian development Abstract: In mammals, repression of germline-specific gene expression is essential for preserving somatic cell identity and preventing disease. Germline gene silencing is often dependent on the presence of promoter 5-cytosine DNA methylation (5meC). Early mammalian development, however, is marked…