The Léon Lab contributed to the publication of a new article in Journal of Cell Biology: Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis Abstract: Lipid scramblases allow passive flip-flop of phospholipids between bilayer leaflets, thereby promoting membrane symmetry. At the endoplasmic reticulum (ER), where phospholipid synthesis is restricted to…

The Pintard Lab contributed to the publication of a new article in Journal of Biological Chemistry: The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation Abstract: SETD2 is the primary methyltransferase responsible for generating H3K36me3, an epigenetic mark that is essential for transcriptional regulation and chromatin integrity. SETD2 mutations are frequently observed in…

The Konstantinides Lab published a new article in Developmental Biology: Gene expression cartography of a developing neuronal structure Abstract: Brains are complex structures comprising thousands to billions of neurons that belong to thousands of different neuronal types. These neurons often come from different progenitor domains and have very diverse developmental histories, yet they need to find…

The Ladoux/Mège Lab and the ImagoSeine platform contributed to the publication of a new article in PNAS: Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion Abstract: Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytoplasmic structures physically modulate diffusion…

The Cadoret Lab contributed to a new article publié dans Nature Communications: DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains Abstract : Besides genome-wide patterns of replication timing (RT), some genes display allelic replication asynchrony in stem cells, brought about by stochastic events and genetic polymorphisms. Whether epigenetic modifications control asynchronous…

The Guichet Lab published a new article in Development: Girdin controls the pace of 3D tracheal cell intercalation by coupling adherens junctions to the actin cytoskeleton in Drosophila Abstract: Morphogenesis is orchestrated through coordinated cell movements, including cell intercalation, which drives extensive changes in cell shape and position. This process requires precise regulation of interactions between Adherens…

The Ladoux/Mege Lab published a new article in The European Physical Journal E: Tissue stress measurements with Bayesian inversion stress microscopy Abstract: Cells within biological tissue are constantly subjected to dynamic mechanical forces. Measuring the internal stress of tissues has proven crucial for our understanding of the role of mechanical forces in fundamental biological processes like…

The Duharcourt Lab published a new article in Nature reviews molecular cell biology: Programmed ‘DNA splicing’ removes transposons from genes Duharcourt S. Programmed 'DNA splicing' removes transposons from genes. Nat Rev Mol Cell Biol. 2026 Jan 5. doi: 10.1038/s41580-025-00943-z. Epub ahead of print. PMID: 41491422.