The ImagoSeine platorm contributed to the publication of a new article in Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Abstract: Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy. The…

The Romet-Lemonne/Jégou Lab a published a new article in Journal of Cell Biology: Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches   Abstract: Actin filaments often appear as branches, nucleated by the Arp2/3 complex. Arp2 and Arp3 are ATPases, which adopt different nucleotide-dependent conformations. We investigated how the nucleotide state of mammalian Arp2/3 complexes affects branch…

The Conduit lab published a new review in Journal of Neurochemistry: The Golgi as a Microtubule Organiser in Neurons Abstract: Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre (MTOC), neurons also rely on non-centrosomal MTOCs (ncMTOCs) as they…

L'équipe Minc a publié un nouvel article dans Current Biology: A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Abstract: Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks regulate the…

The Borghi lab contributed to the publication of a new article published inThe EMBO Journal: Chromosome condensation mechanically primes the nucleus for mitosis Abstract: Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

The Jackson/Verbavatz lab contributed to the publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Abstract: The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with desmosomes,…

The Borghi lab published a new article in Soft Matter: Charles Murray van Wyk, a discreet pioneer of fibre network mechanics Abstract: In 1946, C. M. van Wyk published a seminal theoretical paper on wool mechanics, explaining why the mechanical stress applied to wool is a function of the inverse cube of its volume. In addition to…

The Ladoux/Mege lab contributes to the publication of a new article in Nature materials : Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts Abstract: Cancer-associated fibroblasts are major architects of the tumour stroma, where their aligned, elongated morphology forms a capsule that mechanically restrains tumour expansion. However, it is unclear how this supracellular organization…

The  ProtéoSeine platform contributed to the publication of a new article in Scientific reports: The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Abstract: BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia.…