The Dumont Lab contributed to a new article published in microPublication Biology: Cell type-specific regulation by different cytokinetic pathways in the early embryo Abstract: Cytokinesis, the physical division of one cell into two, is typically assumed to use the same molecular process across animal cells. However, regulation of cell division can vary significantly among different cell types,…

The ProtéoSeine platform contributed to the publication of a new article dans ACS Chemical Biology: Bioorthogonal Monomycolate of Trehalose Disclosed the O-Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in C. glutamicum   Abstract: Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens. These bacteria…

The Courtier Lab published a new article in Evolutionary Biology: A scenario for an evolutionary selection of ageing Abstract: Signs of ageing become apparent only late in life, after organismal development is finalized. Ageing, most notably, decreases an individual’s fitness. As such, it is most commonly perceived as a non-adaptive force of evolution and considered a…

Isabelle le Parco, and the platform she runs, contributed to the publication of an article in Communications biology: Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation Abstract: Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca2+ waves in the developing…

The Veitia lab published a new article in Trends in Genetics : Emerging links between phase separation and transcription factor haploinsufficiency   Abstract: Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of…

The Greenberg Lab published a new article in Nature structural & Molecular biology: DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency Abstract: In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit the…

The Grange / Geigl Lab published a new article in Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Abstract: Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise location(s)…

The Ribes lab published a new article in Elife: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas   Abstract: Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations in…

The Prioleau Lab published a new article in Nucleic Acids Research : DciA secures bidirectional replication initiation in Vibrio cholerae   Abstract: Replication is initiated bidirectionally in the three domains of life by the assembly of two replication forks at an origin of replication. This is made possible by the recruitment of two replicative helicases to a nucleoprotein platform…

The ProtéoSeine platform contributed to the publication of a new article in Molecular Cell : Cell-cycle-dependent mRNA localization in P-bodies   Abstract: Understanding the dynamics of RNA targeting to membraneless organelles is essential to disentangle their functions. Here, we investigate how P-bodies (PBs) evolve during cell-cycle progression in HEK293 cells. PB purification across the cell cycle uncovers…