The Veitia lab published a new article in Trends in Genetics : Emerging links between phase separation and transcription factor haploinsufficiency   Abstract: Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of…

The Greenberg Lab published a new article in Nature structural & Molecular biology: DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency Abstract: In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit the…

The Grange / Geigl Lab published a new article in Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Abstract: Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise location(s)…

The Ribes lab published a new article in Elife: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas   Abstract: Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations in…

The Prioleau Lab published a new article in Nucleic Acids Research : DciA secures bidirectional replication initiation in Vibrio cholerae   Abstract: Replication is initiated bidirectionally in the three domains of life by the assembly of two replication forks at an origin of replication. This is made possible by the recruitment of two replicative helicases to a nucleoprotein platform…

The ProtéoSeine platform contributed to the publication of a new article in Molecular Cell : Cell-cycle-dependent mRNA localization in P-bodies   Abstract: Understanding the dynamics of RNA targeting to membraneless organelles is essential to disentangle their functions. Here, we investigate how P-bodies (PBs) evolve during cell-cycle progression in HEK293 cells. PB purification across the cell cycle uncovers…

The Courtier Lab published a new article in Scientific Reports: Adhesive and mechanical properties of the glue produced by 25 Drosophila species   Abstract: Drosophila glue, a bioadhesive produced by fly larvae to attach themselves to a substrate for several days, has recently gained attention for its peculiar adhesive and mechanical properties. Although Drosophila glue production was described more than 50 years ago, a…

The Dumont Lab published a new article in Current Biology : Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes   Abstract: During cell division, chromosomes build kinetochores that attach to spindle microtubules. Kinetochores usually form at the centromeres, which contain CENP-A nucleosomes. The outer kinetochore, which is the core attachment…

The Pintard Lab contributed to a new article published in Nucleic Acids Research: Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency   Abstract: Molecular cloning, a routine yet essential technique, relies heavily on efficient ligation, which can be significantly improved using Golden Gate Assembly (GGA). A key component of GGA is the use of type IIS…

The Gazave Lab published a new article in Genome Biology and Evolution: Evolution of apoptotic signalling pathways within lophotrochozoans   Abstract: Apoptosis is the main form of regulated cell death in metazoans. Apoptotic pathways are well characterised in nematode, fly and mammals, leading to a vision of the conservation of apoptotic pathways in metazoans. However, we recently showed…