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Romet-Lemonne/Jegou Lab – Regulation of branched versus linear Arp2/3-generated actin filaments

The Romet-Lemonne/Jegou's Team has just published a new paper in the EMBO Journal. Regulation of branched versus linear Arp2/3-generated actin filaments Abstract Activation of the Arp2/3 complex by VCA-motif-bearing actin nucleation-promoting factors results in the formation of “daughter” actin filaments branching off the sides of pre-existing “mother” filaments. Alternatively, when stimulated by SPIN90, Arp2/3 directly nucleates “linear”…

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Greenberg Lab – Conservation and divergence of canonical and non-canonical imprinting in murids

The Greenberg's team has just published a paper in Genome Biology. Conservation and divergence of canonical and non-canonical imprinting in murids Abstract Background Genomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and behavior. While the rat is widely used to model human pathophysiology, few imprinted…

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Camadro Lab – Extending the Range of SLIM-Labeling Applications: From Human Cell Lines in Culture to Caenorhabditis elegans Whole-Organism Labeling

The Camadro team has just published in Journal of Proteome Research a new paper (in collaboration with ProteoSeine, Dumont Lab and Ladoux/Mège Lab): Extending the Range of SLIM-Labeling Applications: From Human Cell Lines in Culture to Caenorhabditis elegans Whole-Organism Labeling   Abstract The simple light isotope metabolic-labeling technique relies on the in vivo biosynthesis of amino acids from U-[12C]-labeled molecules…

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Minc Lab – Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface

The Minc team has just published a new paper in PNAS:   Size- and position-dependent cytoplasm viscoelasticity through hydrodynamic interactions with the cell surface   Abstract Many studies of cytoplasm rheology have focused on small components in the submicrometer scale. However, the cytoplasm also baths large organelles like nuclei, microtubule asters, or spindles that often take significant portions of…

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Dumont Lab – Synergistic stabilization of microtubules by BUB-1, HCP-1 and CLS-2 controls microtubule pausing and meiotic spindle assembly

The Dumont team has just published a new paper in eLife: Synergistic stabilization of microtubules by BUB-1, HCP-1 and CLS-2 controls microtubule pausing and meiotic spindle assembly   Abstract During cell division, chromosome segregation is orchestrated by a microtubule-based spindle. Interaction between spindle microtubules and kinetochores is central to the bi-orientation of chromosomes. Initially dynamic to allow…

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Romet-Lemonne/Jégou Lab – The Arp2/3 complex contributes to the regeneration of branched actin filament networks

L'équipe Romet-Lemonne/Jégou has just published a new article in Biophysical Journal : (ABSTRACT  VOLUME 122, ISSUE 3, SUPPLEMENT 1, 166A-167A,  FEBRUARY 10, 2023)   The Arp2/3 complex contributes to the regeneration of branched actin filament networks   Actin filaments are one of the indispensable components of almost all cell types. These semi-flexible filaments constitute an important part of the…

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Duharcourt Lab – DNA Modification Patterns Filtering and Analysis Using DNAModAnnot

DNA Modification Patterns Filtering and Analysis Using DNAModAnnot Hardy, A., Duharcourt, S., Defrance, M. (2023). DNA Modification Patterns Filtering and Analysis Using DNAModAnnot. In: H. Oliveira, P. (eds) Computational Epigenomics and Epitranscriptomics. Methods in Molecular Biology, vol 2624. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2962-8_7 Abstract Mapping DNA modifications at the base resolution is now possible…

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Minc Lab – Cell wall dynamics stabilize tip growth in a filamentous fungus

The Minc team has just published a new paper in  PLOS Biology Cell wall dynamics stabilize tip growth in a filamentous fungus   Abstract Hyphal tip growth allows filamentous fungi to colonize space, reproduce, or infect. It features remarkable morphogenetic plasticity including unusually fast elongation rates, tip turning, branching, or bulging. These shape changes are all driven from…

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Veitia Lab – The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors

The Veitia team has just published a new paper in Cancer Research : The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors   Abstract Adult-type granulosa cell tumors (AGCT) are the most common type of malignant ovarian sex cord–stromal tumors. Most AGCTs carry the somatic variant c.402C>G (p.C134W) affecting the transcription factor FOXL2.…

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