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IJM Seminar – Peter Sarkies – 15/09/2023

News18 August 2023
Invited by Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) will give an IJM Seminar entitled: Using evolution to understand epigenetic mechanisms   Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence.  As a result, epigenetics is fundamental…

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Palancade Lab – Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import

Home publis, News17 August 2023
The Palancade Lab contributed to the publication of a new article in Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Abstract: N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein…

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Prioleau Lab – Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates

Home publis, News17 August 2023
The Prioleau Lab recently published a new article in dans Nature Communications: Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Abstract: Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three…

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Veitia Lab – Dominant negative variants and cotranslational assembly of macromolecular complexes

Home publis, News17 August 2023
The Veitia Lab recently published a new article in BioEssays : Dominant negative variants and cotranslational assembly of macromolecular complexes Abstract: Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant-negative (DN)…

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Palancade Lab – Puzzling out nuclear pore complex assembly

Home publis, News17 August 2023
The Palancade lab recently published a new article in FEBS Letters: Puzzling out nuclear pore complex assembly Abstract:  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes are built…

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Post-doc position to study collagen secretion in healthy or fibrotic cells (M/W)

News17 August 2023
Contract Period : 24 months Expected date of employment : 1 December 2023 Apply before August, 31st 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-ISHRAO-001/Default.aspx?lang=EN Missions A post-doctoral research position is available in the "Intracellular compartmentalisation" team at the Institut Jacques Monod (UMR7592CNRS/Université Paris Cité, Paris, France) to work on a project that will study the secretion of extracellular matrix proteins. All animals have an…

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Dumont Lab – An unconventional TOG domain is required for CLASP localization

Home publis, News31 July 2023
The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…

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Post-doc in bioinformatics to study the evolution of Arf family GTPases and their regulators (M/W)

Uncategorized28 July 2023
Contract: 12 months Expected date of employment: 15 September 2023 Apply before August, 11th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-CATJAC-004/Default.aspx?lang=EN Missions The post-doc will be involved in bioinformatics research into the functions of regulators of membrane dynamics in eukaryotic cells. In particular, the project will focus on the functions of the Arf family of GTPase regulators, from archaea to eukaryotes. Activities - Search…

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Postdoctoral fellow in structural analysis of proteins by mass spectrometry M/W

Uncategorized28 July 2023
Contract Period: 24 months Expected date of employment: 11 September 2023 Apply before August, 14th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-GUICHE-002/Default.aspx?lang=EN Missions The person recruited will be responsible for developing and carrying out analyses of intact proteins by mass spectrometry using innovative technologies such as native MS, ion mobility, ECD and SID fragmentation and high-resolution chromatography. Activities The person recruited will develop and…

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Research Engineer Position (M/W)

Uncategorized28 July 2023
Contract duration: 1 year Contract start date: September 11, 2023 Apply before August 15: https://emploi.cnrs.fr/Offres/CDD/UMR7592-BENPAL-008/Default.aspx We are looking for a highly-motivated Research Engineer to be in charge of the DECODERS project, supported by the Labex who am I? (http://www.labex-whoami.org/en/) and hosted by the Institut Jacques Monod (CNRS/Université Paris Cité, Paris 13e, France). Several research groups from the Labex consortium…

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