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Post-doc position to study collagen secretion in healthy or fibrotic cells (M/W)

Contract Period : 24 months Expected date of employment : 1 December 2023 Apply before August, 31st 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-ISHRAO-001/Default.aspx?lang=EN Missions A post-doctoral research position is available in the "Intracellular compartmentalisation" team at the Institut Jacques Monod (UMR7592CNRS/Université Paris Cité, Paris, France) to work on a project that will study the secretion of extracellular matrix proteins. All animals have an…

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Dumont Lab – An unconventional TOG domain is required for CLASP localization

The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…

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Post-doc in bioinformatics to study the evolution of Arf family GTPases and their regulators (M/W)

Contract: 12 months Expected date of employment: 15 September 2023 Apply before August, 11th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-CATJAC-004/Default.aspx?lang=EN Missions The post-doc will be involved in bioinformatics research into the functions of regulators of membrane dynamics in eukaryotic cells. In particular, the project will focus on the functions of the Arf family of GTPase regulators, from archaea to eukaryotes. Activities - Search…

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Postdoctoral fellow in structural analysis of proteins by mass spectrometry M/W

Contract Period: 24 months Expected date of employment: 11 September 2023 Apply before August, 14th 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-GUICHE-002/Default.aspx?lang=EN Missions The person recruited will be responsible for developing and carrying out analyses of intact proteins by mass spectrometry using innovative technologies such as native MS, ion mobility, ECD and SID fragmentation and high-resolution chromatography. Activities The person recruited will develop and…

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Research Engineer Position (M/W)

Contract duration: 1 year Contract start date: September 11, 2023 Apply before August 15: https://emploi.cnrs.fr/Offres/CDD/UMR7592-BENPAL-008/Default.aspx We are looking for a highly-motivated Research Engineer to be in charge of the DECODERS project, supported by the Labex who am I? (http://www.labex-whoami.org/en/) and hosted by the Institut Jacques Monod (CNRS/Université Paris Cité, Paris 13e, France). Several research groups from the Labex consortium…

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Greenberg Lab – A genome-wide screen reveals new regulators of the 2-cell-like cell state

The Greenberg Lab recently contributed to the publication of a new article in Nature Structural & Molecular Biology: A genome-wide screen reveals new regulators of the 2-cell-like cell state Abstract: In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear at…

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Pintard Lab – Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos

The Pintard  lab rencently published in Science Advances: Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Abstract: The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis…

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Cadoret Lab – Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner

The Cadoret Lab recently published in International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Abstract: Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce…

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Minc Lab – Length limitation of astral microtubules orients cell divisions in murine intestinal crypts

The Minc Lab recently published a new article in Developmental Cell: Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Abstract: Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to study spindle…

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ProtéoSeine – Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice

The ProtéoSeine plateform contributed to the publication of a new article in Journal of Cellular and Molecular Medicine: Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice Abstract: Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In…

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