The Veitia lab published a new article in FASEB Journal: Nonlinearities and Switch-Like Behavior in Gene Expression: From Genetics to Biochemistry and Back. Abstract: Many developmental and physiological outcomes depend on transcriptional thresholds or switches. The transcriptional output, ultimately measured as mature RNA, is determined by a series of molecular steps that can introduce thresholds, bottlenecks, or…

The Prioleau Lab published a new article in The FEBS Journal: Ploidy-dependent modulation of DNA replication kinetics in Xenopus Abstract: An important question in cell biology is how DNA replication programs scale with genome size following polyploidization, an evolutionary process that increases DNA content without proportionally extending the cell cycle duration. In particular, comparative analyses across…

The Guichet lab published a new article in mBio: Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina Abstract: Nuclear movement, positioning, and the mechanical constraints applied to the nucleus play important roles in cellular identity, physiology, and gene regulation. This process, known as nuclear…

The Veitia lab published a new article in FASEB Journal: Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs Abstract: FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely understood. Here,…

The Guichet lab contributed to the publication of a new article in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research: Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina Abstract: Microtubule-based organelle…

The Romet-Lemonne/Jégou lab a published a new article in PNAS: Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end Abstract: Significance The cytoskeleton is composed of three types of filaments: actin, microtubules, and intermediate filaments, which coordinate to control cell shape, mechanics, and movement. Among them, the contribution of vimentin intermediate filaments to these…

The ImagoSeine platorm contributed to the publication of a new article in Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Abstract: Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy. The…

The Romet-Lemonne/Jégou Lab a published a new article in Journal of Cell Biology: Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches   Abstract: Actin filaments often appear as branches, nucleated by the Arp2/3 complex. Arp2 and Arp3 are ATPases, which adopt different nucleotide-dependent conformations. We investigated how the nucleotide state of mammalian Arp2/3 complexes affects branch…