The Ladoux/Mège Lab published a new nouvel article PNAS: Regulation of epithelial tissue homeostasis by active transepithelial transport Abstract: Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of osmotic and…

The Ladoux/Mege et Jackson/Verbavatz published a new article "news and views" in Nature : ‘Memory foam’ skeleton in cells helps them to navigate d'Alessandro J, Heuzé ML. 'Memory foam' skeleton in cells helps them to navigate. Nature. 2025 Nov;647(8088):42-44. doi: 10.1038/d41586-025-03448-z. PMID: 41184472.

The Ribes / Nedelec Lab published a new article in PLOS Biology: Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Abstract: Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and genetically modulating…

The Dumont Lab published a new article in Journal of Cell Biology: Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation The Minc Lab also contributed to this article. Abstract: Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and anaphase B, in which the anaphase…

The ProtéoSeine platform contributed to the publication of a new article in Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Abstract: The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify…

The Duharcourt Lab published a new article in Nucleic Acids Research: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium The Institut Jacques Monod's ProtéoSeine platform contributed to this article. Abstract: To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs,…