The Wassmann Lab published a new article in EMBO Reports: Oocyte selection: a tale of individualism, dominance and sacrifice Abstract: Oocyte development is a fierce competitive process in which only a small fraction of germ cells survives massive waves of cell death to become a fertilizable egg. Using an ex vivo 4D imaging system, Zhang and…

The Borghi Lab contributed to the publication of a new article in Microbiological Research: Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion Abstract: Chlamydia trachomatis (Ct), a Gram-negative obligate intracellular pathogen, manipulates host actin dynamics to facilitate its entry, development, and exit. It assembles a dynamic actin cage around its intracellular niche,…

The Borghi lab contributed to the publication of a new article in Nature communications: Meningococci drive host membrane tubulation to recruit their signaling receptors Abstract: Once passed into the bloodstream, bacterial pathogens have a limited time to interact with permissive receptors at the surface of host cells. Neisseria meningitidis has developed an extremely effective strategy allowing it to find…

The Pintard Lab published a new article in The Journal of Cell biology: Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Abstract: Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood. Using Caenorhabditiselegans Katanin, which…

The Veitia Lab published a new article in Molecular & Cellular Proteomics: : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Abstract: Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study aims…

The Ladoux/Mège Lab published a new nouvel article PNAS: Regulation of epithelial tissue homeostasis by active transepithelial transport Abstract: Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of osmotic and…