The Veitia lab  published a new review in Biogerontology: Genome integrity, somatic mutation, and the N-of-1 imperative in aging research Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and somatic…

The Borghi lab published a new article Physical Review E: Nuclear pore complex distribution on the nuclear envelope: Insights into curvature, chromatin, and actin contributions Abstract: The Nuclear Pore Complex (NPC) is an ancestral feature of eukaryotic cells, essential for the exchange of material and information between cytoplasm and nucleoplasm. While typical eukaryotic cells harbor thousands of…

The Ladoux/Mege Lab a published a new review in Trends in Cell Biology: Biophysical principles of cell competition and elimination Highlights Cells within heterogeneous tissues can use forces to outcompete and eliminate cells of lower mechanical fitness through various strategies. Cellular biophysical properties, such as cell–cell or cell–substrate adhesion, force generation and transmission, contractility, and stiffness, can provide…

The ProteoSeine Lab contributed to the publication of a new article inNature Communications: Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events Abstract: Meiotic progression relies on maintaining a precise balance between cyclin B/CDK1 activity and the phosphatase PP2A-B55. The latter is negatively regulated by…

The ProtéoSeine Lab contributed to the publication of a new article in Cell Death & Disease : EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne muscular dystrophy Abstract: Duchenne muscular dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGFβ signaling,…

The Jackson/Verbavatz Lab contributed to a new article published in Journal of Microscopy: Stress and conflict management in core facilities - News from an imaging survey Abstract: While conflict management is a well-known challenge for people working in the service sector, this topic remains largely unexplored in scientific imaging core facilities, despite frequent interactions with diverse users…

The Duharcourt Lab published a new article in Nucleic Acids Research: A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination Abstract: Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium, elimination of transposable elements and their relics requires the PiggyMac (Pgm)…