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ERC Synergy Grants – Stéphane Nedelec

ERC3 days ago
The Institut Jacques Monod congratulates 'Institut Jacques Monod on receiving his ERC Synergy Grant! This project uses organoids and organoid-on-chip technologies to uncover the mechanisms underlying regionalization and layering in the developing human cortex — processes essential for the emergence of cortical function and disrupted in many incurable diseases. By understanding these fundamental mechanisms, we…

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Ribes / Nedelec Lab – Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks

Home publis28 October 2025
The Ribes / Nedelec Lab published a new article in PLOS Biology: Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Abstract: Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and genetically modulating…

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Dumont Lab – Minc Lab – Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation

Home publis28 October 2025
The Dumont Lab published a new article in Journal of Cell Biology: Mechanical coordination between anaphase A and B drives asymmetric chromosome segregation The Minc Lab also contributed to this article. Abstract: Chromosome segregation during anaphase occurs through two mechanistically distinct processes: anaphase A, in which chromosomes move toward spindle poles, and anaphase B, in which the anaphase…

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ProtéoSeine – Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation

Home publis28 October 2025
The ProtéoSeine platform contributed to the publication of a new article in Nature metabolism : Microbial metabolite indole-3-propionic acid drives mitochondrial respiration in CD4+ T cells to confer protection against intestinal inflammation Abstract: The gut microbiota and its metabolites critically regulate immune cell phenotype, function and energy metabolism. We screened a collection of gut microbiota-related metabolites to identify…

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Duharcourt Lab – ProtéoSeine – A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium

Home publis28 October 2025
The Duharcourt Lab published a new article in Nucleic Acids Research: A histone methyltransferase-independent function of PRC2 controls small RNA dynamics during programmed DNA elimination in Paramecium The Institut Jacques Monod's ProtéoSeine platform contributed to this article. Abstract: To limit transposable element (TE) mobilization, most eukaryotes have evolved small RNAs to silence TE activity via homology-dependent mechanisms. Small RNAs,…

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Post-doc in cell biology and genomics in C. elegans (M/F)

IJM Job offers27 October 2025
General information Offer title : Post-doc in cell biology and genomics in C. elegans (M/F) (H/F) Reference : UMR7592-JULDUM-010 Number of position : 1 Workplace : PARIS 13 Date of publication : 17 October 2025 Type of Contract : Researcher in FTC Contract Period : 36 months Expected date of employment : 5 January 2026 Proportion of work : Full Time Remuneration : From €3,080 gross per month Desired level of…

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Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection

IJM Job offers16 October 2025
General information Offer title : Postdoctoral Researcher (M/F) in Biophysics of Bacterial Infection (H/F) Reference : UMR7592-DARBON-004 Number of position : 1 Workplace : PARIS 13 Date of publication : 16 October 2025 Type of Contract : Researcher in FTC Contract Period : 24 months Expected date of employment : 1 January 2026 Proportion of work : Full Time Remuneration : From €3,041.58 gross monthly Desired level of education : Doctorate Experience required…

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Borghi Lab – Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy

Home publis15 October 2025
The Borghi Lab published a new article in PLoS Computational Biology: Deep learning detection of dynamic exocytosis events in fluorescence TIRF microscopy   Abstract: Segmentation and detection of biological objects in fluorescence microscopy is of paramount importance in cell imaging. Deep learning approaches have recently shown promise to advance, automatize and accelerate analysis. However, most of the interest…

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Léon Lab – A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition

Home publis13 October 2025
The Léon Lab published, in collaboration with the  ProtéoSeine platform, a new article in Plos Genetics: A genetic screen reveals a key role for Reg1 in 2-deoxyglucose sensing and yeast AMPK inhibition   Abstract: The yeast Saccharomyces cerevisiae thrives in sugar-rich environments by rapidly consuming glucose and favoring alcoholic fermentation. This strategy is tightly regulated by the glucose repression pathway,…

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