L'équipe Minc a publié un nouvel article dans Current Biology: A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Abstract: Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks regulate the…

The Borghi lab contributed to the publication of a new article published inThe EMBO Journal: Chromosome condensation mechanically primes the nucleus for mitosis Abstract: Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

The Jackson/Verbavatz lab contributed to the publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Abstract: The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with desmosomes,…

The Borghi lab published a new article in Soft Matter: Charles Murray van Wyk, a discreet pioneer of fibre network mechanics Abstract: In 1946, C. M. van Wyk published a seminal theoretical paper on wool mechanics, explaining why the mechanical stress applied to wool is a function of the inverse cube of its volume. In addition to…

The Ladoux/Mege lab contributes to the publication of a new article in Nature materials : Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts Abstract: Cancer-associated fibroblasts are major architects of the tumour stroma, where their aligned, elongated morphology forms a capsule that mechanically restrains tumour expansion. However, it is unclear how this supracellular organization…

The  ProtéoSeine platform contributed to the publication of a new article in Scientific reports: The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Abstract: BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia.…

The  Konstantinides contributed to the publication of a new article in Cell Reports: Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila Abstract: Locomotor skills arise early in life and are maintained throughout an animal’s lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show that the…

The Romet-Lemonne/Jégou lab published a new article in Cell Reports: Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts Abstract: Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for actin from…