The Ladoux/Mege Lab a published a new review in Trends in Cell Biology: Biophysical principles of cell competition and elimination Highlights Cells within heterogeneous tissues can use forces to outcompete and eliminate cells of lower mechanical fitness through various strategies. Cellular biophysical properties, such as cell–cell or cell–substrate adhesion, force generation and transmission, contractility, and stiffness, can provide…

The ProteoSeine Lab contributed to the publication of a new article inNature Communications: Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events Abstract: Meiotic progression relies on maintaining a precise balance between cyclin B/CDK1 activity and the phosphatase PP2A-B55. The latter is negatively regulated by…

The ProtéoSeine Lab contributed to the publication of a new article in Cell Death & Disease : EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne muscular dystrophy Abstract: Duchenne muscular dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGFβ signaling,…

The Jackson/Verbavatz Lab contributed to a new article published in Journal of Microscopy: Stress and conflict management in core facilities - News from an imaging survey Abstract: While conflict management is a well-known challenge for people working in the service sector, this topic remains largely unexplored in scientific imaging core facilities, despite frequent interactions with diverse users…

The Duharcourt Lab published a new article in Nucleic Acids Research: A developmental condensin I complex assists the Paramecium PiggyMac domesticated transposase during programmed DNA elimination Abstract: Prokaryotes and eukaryotes use diverse strategies to cope with invading mobile genetic elements, including programmed DNA elimination (PDE). In the ciliate Paramecium, elimination of transposable elements and their relics requires the PiggyMac (Pgm)…

The Ladoux/Mege lab published a new article in Science Advances: Dynamic heterogeneity and hidden fluidity in dense epithelial tissues Abstract: Epithelial tissues maintain organ integrity while continuously remodeling during morphogenesis, repair, and disease. At high cell densities, these tissues often appear mechanically arrested in a disordered, solid-like state, raising the question of how they retain the ability…

The chromosomal origin of replication as the basis for the spatio-temporal biology of bacteria Abstract: Spatial biology depends on the structural dynamics of the constituents of the cell. We propose that such dynamics during the cell cycle depend to a large extent on the origin of replication and its role in the trajectory of a replication…

The former Camadro Lab contributed to the publication of a new article in The ISME Journal : Iron limitation promotes metabolic cross-feeding between cheese ripening bacteria Abstract: Iron is a limiting micronutrient in various environments, and its scarcity orchestrates microbial interactions across diverse ecosystems. The cheese surface, which is oxic, iron-limited, and a host of moderately complex…