The Ladoux/Mege lab contributes to the publication of a new article in Nature materials : Fibronectin matrix remodelling modulates the active nematic dynamics of cancer-associated fibroblasts Abstract: Cancer-associated fibroblasts are major architects of the tumour stroma, where their aligned, elongated morphology forms a capsule that mechanically restrains tumour expansion. However, it is unclear how this supracellular organization…

The  ProtéoSeine platform contributed to the publication of a new article in Scientific reports: The ITM2B-associated retinal dystrophy mutation modifies BRI23 peptide interactions in the human retina Abstract: BRI23, composed of the 23 last amino acids of the integral transmembrane protein 2B (ITM2B) C-terminus, is associated with several neurodegenerative diseases, including retinal dystrophy (RD) and familial dementia.…

The  Konstantinides contributed to the publication of a new article in Cell Reports: Embryonic dopaminergic neuron activity sustains lifelong locomotion in Drosophila Abstract: Locomotor skills arise early in life and are maintained throughout an animal’s lifespan, yet how this continuity is achieved despite major neural remodeling remains unclear. Using Drosophila, which undergoes complete metamorphosis, we show that the…

The Romet-Lemonne/Jégou lab published a new article in Cell Reports: Rapid aging and disassembly of actin filaments from two evolutionary distant yeasts Abstract: Similarities and differences in the self-assembly of actin filaments from different species inform our understanding of its evolution. However, this basic knowledge is largely incomplete. Here, we systematically characterize assembly kinetics for actin from…

The Veitia lab  published a new review in Biogerontology: Genome integrity, somatic mutation, and the N-of-1 imperative in aging research Aging research has made remarkable progress in describing aging through the genetic architecture of longevity, epigenetic clocks, proteomic signatures, and systems-level analyses. Yet a critical dimension remains underrepresented: the role of genome integrity, germline and somatic…

The Borghi lab published a new article Physical Review E: Nuclear pore complex distribution on the nuclear envelope: Insights into curvature, chromatin, and actin contributions Abstract: The Nuclear Pore Complex (NPC) is an ancestral feature of eukaryotic cells, essential for the exchange of material and information between cytoplasm and nucleoplasm. While typical eukaryotic cells harbor thousands of…

The Ladoux/Mege Lab a published a new review in Trends in Cell Biology: Biophysical principles of cell competition and elimination Highlights Cells within heterogeneous tissues can use forces to outcompete and eliminate cells of lower mechanical fitness through various strategies. Cellular biophysical properties, such as cell–cell or cell–substrate adhesion, force generation and transmission, contractility, and stiffness, can provide…

The ProteoSeine Lab contributed to the publication of a new article inNature Communications: Greatwall depletion from Xenopus oocytes reveals a key role of the cyclin B/CDK1-PP2A-B55 balance in the coordination of meiotic events Abstract: Meiotic progression relies on maintaining a precise balance between cyclin B/CDK1 activity and the phosphatase PP2A-B55. The latter is negatively regulated by…