The Conduit lab published a new review in Journal of Neurochemistry: The Golgi as a Microtubule Organiser in Neurons Abstract: Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre (MTOC), neurons also rely on non-centrosomal MTOCs (ncMTOCs) as they…

L'équipe Minc a publié un nouvel article dans Current Biology: A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos Abstract: Nuclei and mitotic spindles are actively positioned at defined locations within cells to regulate cell polarity, division, and multicellular morphogenesis.1 ,2 ,3 ,4  Forces generated by cytoskeleton networks regulate the…

The Borghi lab contributed to the publication of a new article published inThe EMBO Journal: Chromosome condensation mechanically primes the nucleus for mitosis Abstract: Accurate transition into mitosis driven by cyclin B1-CDK1 activity is essential to avoid chromosome segregation errors and preserve genome integrity. How this activity is spatially controlled to trigger mitotic onset remains unclear.…

The Jackson/Verbavatz lab contributed to the publication d'un nouvel article dans Cell Reports: Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites Abstract: The spatial organization and dynamics of the endoplasmic reticulum (ER) govern when and where ER tubules engage with other organelles and the plasma membrane. We previously found that ER tubules are closely associated with desmosomes,…

The Borghi lab published a new article in Soft Matter: Charles Murray van Wyk, a discreet pioneer of fibre network mechanics Abstract: In 1946, C. M. van Wyk published a seminal theoretical paper on wool mechanics, explaining why the mechanical stress applied to wool is a function of the inverse cube of its volume. In addition to…