The Pintard Lab published a new article in The Journal of Cell biology: Intramolecular regulation of the MT-severing enzyme Katanin prevents futile ATP hydrolysis Abstract: Microtubule-severing enzymes are evolutionarily conserved AAA-ATPases that sever microtubules, thereby regulating diverse microtubule-dependent cellular processes. How these enzymes couple Microtubule binding with ATP hydrolysis to trigger microtubule-remodeling remains poorly understood. Using Caenorhabditiselegans Katanin, which…

The Veitia Lab published a new article in Molecular & Cellular Proteomics: : Deciphering the impact of AKT1 pathogenic variants in Juvenile Granulosa Cell Tumors Using a Drosophila model.   Abstract: Background Juvenile-type granulosa cell tumors (JGCTs) manifest during the prepubertal period as precocious pseudo-puberty and/or dysmenorrhea. We have previously identified pathogenic variants in AKT1 in JGCTs. This study aims…

The Ladoux/Mège Lab published a new nouvel article PNAS: Regulation of epithelial tissue homeostasis by active transepithelial transport Abstract: Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties of extracellular matrix, a interesting mechanobiological paradigm highlights the role of osmotic and…

The Ladoux/Mege et Jackson/Verbavatz published a new article "news and views" in Nature : ‘Memory foam’ skeleton in cells helps them to navigate d'Alessandro J, Heuzé ML. 'Memory foam' skeleton in cells helps them to navigate. Nature. 2025 Nov;647(8088):42-44. doi: 10.1038/d41586-025-03448-z. PMID: 41184472.

The Ribes / Nedelec Lab published a new article in PLOS Biology: Dual transcriptional activities of PAX3 and PAX7 spatially encode spinal cell fates through distinct gene networks   Abstract: Understanding how transcription factors regulate organized cellular diversity in developing tissues remains a major challenge due to their pleiotropic functions. We addressed this by monitoring and genetically modulating…