The Guichet lab published a new article in mBio: Fast and tortuous: extreme deformations and fast movements of the cell nucleus are driven by microtubules in the model fungus Podospora anserina Abstract: Nuclear movement, positioning, and the mechanical constraints applied to the nucleus play important roles in cellular identity, physiology, and gene regulation. This process, known as nuclear…

The Veitia lab published a new article in FASEB Journal: Modification of the Transcription Factor FOXL2 at Serines 101 and 107 Disables DNA Binding, Leads to Nucleolar Relocalization, and Rewires Granulosa-Cell Programs Abstract: FOXL2 is a forkhead transcription factor (TF) essential for granulosa-cell identity and function, yet how post-translational modifications tune its activity remains incompletely understood. Here,…

The Guichet lab contributed to the publication of a new article in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research: Kinesin-3 and the cargo adaptor Hook1 regulate early endosome and peroxisome motility and are required for mitochondrial and endoplasmic reticulum spatial organization during polarized fungal cell growth in Podospora anserina Abstract: Microtubule-based organelle…

The Romet-Lemonne/Jégou lab a published a new article in PNAS: Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end Abstract: Significance The cytoskeleton is composed of three types of filaments: actin, microtubules, and intermediate filaments, which coordinate to control cell shape, mechanics, and movement. Among them, the contribution of vimentin intermediate filaments to these…

The ImagoSeine platorm contributed to the publication of a new article in Biomacromolecules : Nanoscale Structural Insights into Human Pulmonary Mucus and Its Snail Slime-Based Surrogate Using Automated TEM Image Processing Abstract: Pulmonary drug delivery is a promising approach for treating respiratory diseases, but the mucus barrier in bronchial airways often hinders therapeutic efficacy. The…

The Romet-Lemonne/Jégou Lab a published a new article in Journal of Cell Biology: Inorganic phosphate rapidly switches the stability of Arp2/3-induced actin branches   Abstract: Actin filaments often appear as branches, nucleated by the Arp2/3 complex. Arp2 and Arp3 are ATPases, which adopt different nucleotide-dependent conformations. We investigated how the nucleotide state of mammalian Arp2/3 complexes affects branch…

The Conduit lab published a new review in Journal of Neurochemistry: The Golgi as a Microtubule Organiser in Neurons Abstract: Microtubules are fundamental to neuronal architecture, providing the structural framework and transport tracks essential for polarisation, compartmentalisation and growth. While the centrosome is the canonical microtubule-organising centre (MTOC), neurons also rely on non-centrosomal MTOCs (ncMTOCs) as they…