The Romet-Lemonne/Jégou Lab published a new nouvel article in The European Physical Journal E: Probing protein–protein interactions with drag flow: a case study of F-actin and tropomyosin Abstract: Tropomyosins are central regulators of the actin cytoskeleton, controlling the binding and activity of the other actin binding proteins. The interaction between tropomyosin and actin is quite unique:…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Communications : UHRF2 mediates resistance to DNA methylation reprogramming in primordial germ cells   Abstract: In mammals, primordial germ cells (PGCs) undergo global erasure of DNA methylation with delayed demethylation of germline genes and selective retention of DNA methylation at evolutionarily young retrotransposons. However, the molecular mechanisms of…

The Wassmann published a new article in EMBO: Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II Abstract: The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II. In mammalian oocytes, separase…

The Minc Lab contributed to the publication of a new article in Biophysical Journal: Inferring diffusion, reaction, and exchange parameters from imperfect FRAP Abstract: Fluorescence recovery after photobleaching (FRAP) is broadly used to investigate the dynamics of molecules in cells and tissues, notably to quantify diffusion coefficients. FRAP is based on the spatiotemporal imaging of fluorescent molecules…

The Ribes/Nedelec Lab contributed to the publication to a new article Science Advances: GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration   Abstract: The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through GPR161. Using…

The Wassmann Lab contributes to the book Mammalian Oocyte Development: “JessTM Simple WesternTM”: A New Technology to Assess Protein Abundance in Mouse Oocytes Abstract: Traditional Western blot technology coupled with two-dimensional  SDS-PAGE has been used for decades to detect specific proteins in extracts. Here we describe an automated Western technology based on protein separation by capillary assay. Only…

The Jackson/Verbavatz Lab contributes to the publication of a new article in Traffic: Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases Abstract: Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we focused…

The Gazave contribued to a new article published in BMC Genomics: A genome resource for the marine annelid Platynereis spp Abstract: The marine annelid Platynereis dumerilii is a model organism used in many research areas including evolution and development, neurobiology, ecology and regeneration. Here we present the genomes of P. dumerilii (laboratory culture reference and a single…

The Veitia Lab published a new article in Journal of inherited metabolic disease: Gene Dosage Sensitivity and Human Genetic Diseases Abstract: Here we review the historical background and contemporary insights into genetic dominance, focusing on haploinsufficiency (HI), that is, when the function of only one allele of a gene is not enough to ensure a normal phenotype…