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Collignon Lab – Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration

The Collignon Lab contributed to the publication of a new article in PNAS: Neural crest cell recruitment and reprogramming as central drivers of embryonic limb regeneration Abstract: Significance Mouse embryos possess the remarkable ability to regenerate amputated forelimb buds at E10.5—a capacity lost just 2 d later. We identify neural crest cells (NCCs) as key drivers in…

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Ladoux/Mege Lab – Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization

The Ladoux-Mège Lab contributed to the publication of a new article in Science advances: Actomyosin-dependent assembly of the mechanosensitive machinery from adherens junctions triggers actin polymerization and organization Abstract: Cells rely on cadherin-based adherens junctions (AJs) to form cohesive tissues. To establish contact, cells generate pushing forces through branched actin polymerization mediated by the actin-related protein 2/3…

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Borghi Lab – Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion

The Borghi Lab contributed to the publication of a new article in Microbiological Research: Chlamydia trachomatis highjacks host MYO1C for actin cage recruitment at the bacterial inclusion Abstract: Chlamydia trachomatis (Ct), a Gram-negative obligate intracellular pathogen, manipulates host actin dynamics to facilitate its entry, development, and exit. It assembles a dynamic actin cage around its intracellular niche,…

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Borghi Lab – Meningococci drive host membrane tubulation to recruit their signaling receptors

The Borghi lab contributed to the publication of a new article in Nature communications: Meningococci drive host membrane tubulation to recruit their signaling receptors Abstract: Once passed into the bloodstream, bacterial pathogens have a limited time to interact with permissive receptors at the surface of host cells. Neisseria meningitidis has developed an extremely effective strategy allowing it to find…

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