The Palancade lab published a new article in Nucleic Acid Research: RNA exosome-driven RNA processing instructs the duration of the unfolded protein response Abstract: Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbations, these pathways are typically maintained at a basal level, activated upon stress, and critically downregulated…

The Pintard Lab published a new article in The EMBO Journal: The MAST kinase KIN-4 carries out mitotic entry functions of Greatwall in C. elegans   Abstract: MAST-like, or Greatwall (Gwl), an atypical protein kinase related to the evolutionarily conserved MAST kinase family, is crucial for cell cycle control during mitotic entry. Mechanistically, Greatwall is activated by Cyclin B-Cdk1…

The Léon Lab published a nouvel article dans Biology of the cell: Direct observation of fluorescent proteins in gels: A rapid, cost-efficient, and quantitative alternative to immunoblotting Abstract: Background Information The discovery of green fluorescent protein (GFP) and its derivatives has revolutionized cell biology. These fluorescent proteins (FPs) have enabled the real-time observation of protein localization and…

The Wassmann lab published a new preprint: Elimination of separase inhibition reveals absence of cohesin protection in oocyte metaphase II   Résumé: The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the centromere region in meiosis II. In mammalian oocytes, separase…

The Romet-Lemonne/Jégou  Lab published a new review in Annual review of Biophysics: Mechanics of Single Cytoskeletal Filaments   Abstract: The cytoskeleton comprises networks of different biopolymers, which serve various cellular functions. To accomplish these tasks, their mechanical properties are of particular importance. Understanding them requires detailed knowledge of the mechanical properties of the individual filaments that make up…

The Borghi lab published a review in Front. Cell Dev: Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties   Abstract: Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated…

The Borghi lab published an article in Biophysical Journal: Tension makes the cell throw up   Lachuer H. Tension makes the cell throw up. Biophys J. 2025 Jan 3:S0006-3495(24)04128-6. doi: 10.1016/j.bpj.2024.12.033. Epub ahead of print. PMID: 39889700.

The Jackson/Verbavatz Lab published a new article Nature Microbiology: The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics   Abstract: The evolution of eukaryotes is a fundamental event in the history of life. The closest prokaryotic lineage to eukaryotes, the Asgardarchaeota, encode proteins previously found only in eukaryotes, providing insight into their archaeal ancestor.…

The Prioleau publisehd a new article in Nucleic Acid Research: Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus   Abstract: Les génomes des vertébrés se dupliquent en activant des dizaines de milliers d'origines de réplication de l'ADN, réparties de manière irrégulière le long du génome. Cependant, en l'absence d'une séquence…