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IJM Seminar – Takashi Hiiragi – 28/10/2022

News17 October 2022
Invited by Jérôme Collignon, Takashi Hiiragi (Hubrecht Institute, Utrecht, The Netherlands /ASHBi Kyoto University, Kyoto, Japan) will give a seminar entitled: Multicellular coordination in context   The Hiiragi group studies robustness in development and aims to understand the design principle of self-organising multi-cellular systems. Self-organisation is a defining feature of living systems and entails complex interplay between molecular,…

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IJM Seminar – Ada Cavalcanti – 21/10/2022

News17 October 2022
Invited by Benoit Ladoux, Ada Cavalcanti (Max Planck Institute for Medical Research) will give a seminar entitled: Mechanical regulation of receptor-mediated cell adhesion   Growth Factor Mechanobiology Group leader: Priv. Doz. Dr. Dr. E. Ada Cavalcanti-Adam Mechanical forces exerted by cells during adhesion and migration are adjusted through molecular interactions of receptors at the cell membrane. Adhesive molecules…

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Camadro Lab – Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death

Home publis, News13 October 2022
A new paper just published in Cancers : Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Abstract Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR).…

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Wassmann Lab – Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

Home publis, News3 October 2022
The Wassmann team has just published a new paper in Developmental Cell: Cyclin B3 implements timely vertebrate oocyte arrest for fertilization Summary To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how this arrest is implemented exclusively…

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IJM Seminar – Olivier Tenaillon – 14/10/2022

News3 October 2022
Invited by Virginie Courtier, Olivier Tenaillon (Inserm, Université Paris Cité) will give on October 14th a seminar entitled : "Molecular determinants of bacterial adaptation in vitro, in vivo, in infectio. " Research interests     With the rise of antibiotic resistance and the emergence of new forms of virulence, it has become clear that microbial evolution is…

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Wassmann Lab – Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor

Home publis, News29 September 2022
The Wassmann Team has just published a new paper in Star Protocols! Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor   Summary Here, we describe a biosensor to assess meiotic cohesin subunit Rec8 cleavage in mouse oocytes. We detail oocyte collection and microinjection of the mRNA…

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Ladoux/Mège Lab – The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

Home publis, News16 September 2022
The Ladoux/Mège Team has just published a new paper in Science Advances: The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces   Abstract Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous…

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