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IJM Seminar – Peter Sarkies – 15/09/2023

News18 August 2023
Invited by Sandra Duharcourt, Peter Sarkies (Department of Biochemistry, University of Oxford) will give an IJM Seminar entitled: Using evolution to understand epigenetic mechanisms   Epigenetics and Evolution Epigenetics allows different types of cells in the body to turn different sets of genes on or off without changing the underlying DNA sequence.  As a result, epigenetics is fundamental…

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Palancade Lab – Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import

Home publis, News17 August 2023
The Palancade Lab contributed to the publication of a new article in Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Abstract: N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein…

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Prioleau Lab – Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates

Home publis, News17 August 2023
The Prioleau Lab recently published a new article in dans Nature Communications: Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Abstract: Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three…

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Veitia Lab – Dominant negative variants and cotranslational assembly of macromolecular complexes

Home publis, News17 August 2023
The Veitia Lab recently published a new article in BioEssays : Dominant negative variants and cotranslational assembly of macromolecular complexes Abstract: Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency. Dominant-negative (DN)…

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Palancade Lab – Puzzling out nuclear pore complex assembly

Home publis, News17 August 2023
The Palancade lab recently published a new article in FEBS Letters: Puzzling out nuclear pore complex assembly Abstract:  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes are built…

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Post-doc position to study collagen secretion in healthy or fibrotic cells (M/W)

News17 August 2023
Contract Period : 24 months Expected date of employment : 1 December 2023 Apply before August, 31st 2023: https://emploi.cnrs.fr/Offres/CDD/UMR7592-ISHRAO-001/Default.aspx?lang=EN Missions A post-doctoral research position is available in the "Intracellular compartmentalisation" team at the Institut Jacques Monod (UMR7592CNRS/Université Paris Cité, Paris, France) to work on a project that will study the secretion of extracellular matrix proteins. All animals have an…

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Dumont Lab – An unconventional TOG domain is required for CLASP localization

Home publis, News31 July 2023
The Dumont Lab recently published an article in Current Biology: An unconventional TOG domain is required for CLASP localization Abstract: Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene (TOG)…

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Greenberg Lab – A genome-wide screen reveals new regulators of the 2-cell-like cell state

Home publis, News26 July 2023
The Greenberg Lab recently contributed to the publication of a new article in Nature Structural & Molecular Biology: A genome-wide screen reveals new regulators of the 2-cell-like cell state Abstract: In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear at…

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Pintard Lab – Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos

Home publis, News24 July 2023
The Pintard  lab rencently published in Science Advances: Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Abstract: The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis…

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Cadoret Lab – Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner

Home publis, News20 July 2023
The Cadoret Lab recently published in International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Abstract: Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce…

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