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Grange / Geigl Lab – SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase

Home publis21 August 2024
The Grange/Geigl Lab contributed to the publication to a new in Annals of Rheumatic Diseases : SerpinA3N limits cartilage destruction in osteoarthritis by inhibiting macrophage-derived leucocyte elastase   Abstract: Objectives Inflammatory mediators such as interleukin 6 (IL-6) are known to activate catabolic responses in chondrocytes during osteoarthritis (OA). This study aimed to investigate the role of a downstream target…

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Minc Lab – Mechanical strategies supporting growth and size diversity in Filamentous Fungi

Home publis21 August 2024
The Minc Lab published a nex article in Molecular Biology of the Cell : Mechanical strategies supporting growth and size diversity in Filamentous Fungi   Abstract: The stereotypical tip growth of filamentous fungi supports their lifestyles and functions. It relies on the polarized remodeling and expansion of a protective elastic cell wall (CW) driven by large cytoplasmic turgor…

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Dumont Lab – Maternal inheritance of functional centrioles in two parthenogenetic nematodes

Home publis21 August 2024
The Dumont Lab published a new article in Nature Communication: Maternal inheritance of functional centrioles in two parthenogenetic nematodes   Abstract: Centrioles are the core constituent of centrosomes, microtubule-organizing centers involved in directing mitotic spindle assembly and chromosome segregation in animal cells. In sexually reproducing species, centrioles degenerate during oogenesis and female meiosis is usually acentrosomal. Centrioles are…

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Raote Lab – Endoplasmic reticulum exit sites are segregated for secretion based on cargo size

Home publis21 August 2024
The Raote Lab contributed to the publication of a new article in Developmental Cell: Endoplasmic reticulum exit sites are segregated for secretion based on cargo size   Abstract: TANGO1, TANGO1-Short, and cTAGE5 form stable complexes at the endoplasmic reticulum exit sites (ERES) to preferably export bulky cargoes. Their C-terminal proline-rich domain (PRD) binds Sec23A and affects COPII assembly. The PRD in TANGO1-Short…

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Conduit Lab – Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation

Home publis, News2 July 2024
The Conduit Lab published a new  review in Nature Structural & Molecular Biology: Cryo-EM structures of γ-TuRC reveal molecular insights into microtubule nucleation   Abstract: Microtubules within cells often have 13 protofilaments but are nucleated by multi-protein y-TuRCs complexes that display 14 γ-tubulin molecules. High-resolution cryo-EM structures of γ-TuRCs after nucleation show that these γ-TuRCs ‘close’ during nucleation…

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Gazave Lab – Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis

Home publis, News2 July 2024
The Gazave published a new article in Development: Variations in cell plasticity and proliferation underlie distinct modes of regeneration along the antero-posterior axis in the annelid Platynereis   Abstract: The capacity to regenerate lost tissues varies significantly among animals. Some phyla, such as the annelids, display substantial regenerating abilities, although little is known about the cellular mechanisms…

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Konstantinides Lab – Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance

Home publis, News2 July 2024
The Konstantinides Lab published a new article in CSH Perspectives: Neuronal Circuit Evolution: From Development to Structure and Adaptive Significance   Abstract: Neuronal circuits represent the functional units of the brain. Understanding how the circuits are generated to perform computations will help us understand how the brain functions. Nevertheless, neuronal circuits are not engineered, but have formed through…

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Grange/Geigl Lab – Arrival of steppe-ancestry in the north of France observed in real-time explains the shaping of the European genome

Home publis, News19 June 2024
The Grange/Geigl Lab published a new article in Science Advances: Arrival of steppe-ancestry in the north of France observed in real-time explains the shaping of the European genome   The last major migratory wave that shaped the European genome was that of the populations from the steppes north of the Black Sea ~5,000 years. These steppe pastoralists…

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IJM – Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting

Home publis, News3 June 2024
Researchers at the Institut Jacques Monod have published a collaborative study ( preprint) on the conditions of use of various GFP and RFP for the direct detection of fluorescence in gels: Direct observation of fluorescent proteins in gels: a rapid, cost-efficient and quantitative alternative to immunoblotting   Abstract: The discovery of Green Fluorescent Protein (GFP) and its derivatives…

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