The Wassmann lab published a new preprint: Elimination of separase inhibition reveals absence of cohesin protection in oocyte metaphase II   Résumé: The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the centromere region in meiosis II. In mammalian oocytes, separase…

The Romet-Lemonne/Jégou  Lab published a new review in Annual review of Biophysics: Mechanics of Single Cytoskeletal Filaments   Abstract: The cytoskeleton comprises networks of different biopolymers, which serve various cellular functions. To accomplish these tasks, their mechanical properties are of particular importance. Understanding them requires detailed knowledge of the mechanical properties of the individual filaments that make up…

The Borghi lab published a review in Front. Cell Dev: Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties   Abstract: Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated…

The Borghi lab published an article in Biophysical Journal: Tension makes the cell throw up   Lachuer H. Tension makes the cell throw up. Biophys J. 2025 Jan 3:S0006-3495(24)04128-6. doi: 10.1016/j.bpj.2024.12.033. Epub ahead of print. PMID: 39889700.

The Jackson/Verbavatz Lab published a new article Nature Microbiology: The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics   Abstract: The evolution of eukaryotes is a fundamental event in the history of life. The closest prokaryotic lineage to eukaryotes, the Asgardarchaeota, encode proteins previously found only in eukaryotes, providing insight into their archaeal ancestor.…

The Prioleau publisehd a new article in Nucleic Acid Research: Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus   Abstract: Les génomes des vertébrés se dupliquent en activant des dizaines de milliers d'origines de réplication de l'ADN, réparties de manière irrégulière le long du génome. Cependant, en l'absence d'une séquence…

The Doye Lab published a new article in Current Opinion in Cell Biology : Opening the gate: Complexity and modularity of the nuclear pore scaffold and basket   Résumé: Nuclear pore complexes (NPCs) are giant molecular assemblies that form the gateway between the nucleus and the cytoplasm and accommodate the bidirectional transport of a large variety of…

The Protéoseine platform contributed to the publication of an article in Journal of Proteome Research: Molecular Mechanisms of Acanthamoeba castellanii Response to Different Sources of Oxidative Stress   Abstract: Oxidative stress is a biological principle affecting all life on Earth and is also an important factor in the pathogen-host relationship. The pathogenic free-living amoeba Acanthamoeba castellanii has several pathways to cope…

The Gazave Lab contributed to the publication of a new article in Science Advances: A positive feedback loop between germ cells and gonads induces and maintains sexual reproduction in a cnidarian   Abstract: The fertile gonad includes cells of two distinct developmental origins: the somatic mesoderm and the germ line. How somatic and germ cells interact to develop…

The Minc lab and Dumont lab published a report in Current Biology: Cell shape modulates mitotic spindle positioning forces via intracellular hydrodynamics   Abstract: The regulation of mitotic spindle positioning and orientation is central to the morphogenesis of developing embryos and tissues.1 ,2 ,3 ,4 ,5  In many multicellular contexts, cell geometry…