The Courtier lab recently published a new article in Plos one: Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries   Abstract: During COVID-19 pandemic several public health measures were implemented by diverse countries to reduce the risk of COVID-19, including social distancing. Here we collected the minimal distance recommended by each country for…

The Léon lab contributed to a new article published in Molecular Cell: Ubiquiton - An inducible, linkage-specific polyubiquitylation tool   Abstract: The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools to induce linkage-specific polyubiquitylation of a protein…

The Camadro Lab published a new article in NAR Genomics & Bioinformatics: 3D models of fungal chromosomes to enhance visual integration of omics data   Abstract: The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D organization by probing chromatin interactions. Standard representation of…

The Borghi Lab contributed to a new article published in Experimental Hematology & Oncology: ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells   Abstract: Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing…

The Collignon Lab recently published a new article in Non-coding RNA : LADON , a Natural Antisense Transcript of NODAL , Promotes Tumour Progression and Metastasis in Melanoma   Abstract: The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in melanoma…

The Minc Lab recently published a new article in Cell Dynamics: Cytoplasm mechanics and cellular organization   Abstract: As cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by the surrounding…

The Cadoret Lab contributed to the publication of a new article in EMBO reports: The nucleolar protein GNL3 prevents resection of stalled replication forks   Abstract: Faithful DNA replication requires specific proteins that protect replication forks and so prevent the formation of DNA lesions that may damage the genome. Identification of new proteins involved in this process is…

The Konstantinides Lab published a new article in The FEBS Journal : Evolution of patterning   Abstract: Developing tissues are patterned in space and time; this enables them to differentiate their cell types and form complex structures to support different body plans. Although space and time are two independent entities, there are many examples of spatial patterns that…

The Veitia Lab recently published a new article in Nucleic Acids Research : The forkhead DNA-binding domain binds specific G2-rich RNA sequences   Abstract: Transcription factors contain a DNA-binding domain ensuring specific recognition of DNA target sequences. The family of forkhead (FOX) transcription factors is composed of dozens of paralogs in mammals. The forkhead domain (FHD) is a…

Le  Ladoux / Mège recently contributed to the publication of a new article in Nature Cell biology : A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion Abstract: Invadosomes and caveolae are mechanosensitive structures that are implicated in metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix degradative invadosomes at contact…