Proteomics: Mass Spectrometry
ProteoSeine is the proteomics facility of the Institut Jacques Monod, UMR 7592 Université de Paris Cité – CNRS. It has been located since early 2009 in the Buffon building at 15 rue Hélène Brion, 75205 Paris CEDEX 13 – France. The platform’s activities include analytical services, technical and methodological research and development, and active technology watch. In this context, it uses the most modern approaches of mass spectrometry for the study of protein constituents of living systems.
Its mission is to offer the biology research community state-of-the-art skills and services to integrate proteomic approaches into the development of their scientific projects.
ProteoSeine’s R&D is based on the active research in fundamental biology of the Institut Jacques Monod teams, on collaborations with the hospital sector and on a long-standing know-how in the analytical development of therapeutic proteins. The team is particularly developing its expertise in the high-throughput differential quantitative analysis of complex protein mixtures, the analysis of post-translational modifications, the characterisation of recombinant pharmaceutical proteins and the analysis of non-covalent complexes by mass spectrometry under native conditions. Bottom-up and top-down approaches at the nano or capillary scale are used according to the problems encountered.
The platform is labelled by the GIS IBiSA (Infrastructure for Biology, Health and Agronomy) and by the Cancéropôle Ile-de-France. It is open to the entire national and international, public and private scientific community. The traceability of activities is ensured through the registration of services and users in a LIMS specially developed internally and raw data are stored in redundancy via a solution managed globally by the Institut Jacques Monod. ProteoSeine is also an associate member of ProFi, the national research infrastructure dedicated to proteomic analysis and is supported by the following organisations: