Transcription factor sensitivity to DNA methylation
Multicellular organisms establish and maintain different transcriptional states in disparate cell types through complex and specific regulation of gene expression. This regulation is mediated by the cooperative binding of transcription factors to regulatory elements through the recognition of specific DNA sequence motifs. Additionally, the physical access of transcription factors to DNA can be modulated by epigenetic regulation, such as DNA methylation or nucleosome positioning. Failure to maintain this tight regulation of gene expression results in various diseases including cancer. We use both computational and experimental approaches and integrate genomic data to study transcription factor binding and its regulation in cellular systems.
The seminar will take place on February, Friday 23rd at 11.45 am in room François Jacob.