The Doye Lab recently contributed to the publication of a new article in DNA Repair: Metazoan nuclear pore complexes in gene regulation and genome stability Abstract: The nuclear pore complexes (NPCs), one of the hallmarks of eukaryotic nuclei, allow selective transport of macromolecules between the cytoplasm and the nucleus. Besides this canonical function, an increasing number of additional roles have…

The Greenberg Lab contributed to the publication of a new article in Nucleic Acids Research: A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation   Abstract:  Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements and higher-order chromatin structures. Consequently,…

The Prioleau Lab contributed to the publication of a new article in Nature communications : Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair Abstract: Histone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57…

The Palancade Lab contributed to the publication of a new article in Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Abstract: N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein…