3D genome under stress: How an animal´s nutritional status shapes chromatin architecture
Outside of the lab, all organisms are constantly exposed to a changing environment, such as temperature shifts, a variable availability of nutrients and the presence of pathogens.
All these environmental agents can influence genome regulation at multiple levels via epigenetic mechanisms. Thus, deciphering how the epigenome responds to environmental perturbations is a fundamental open question, with the potential to shed light on diseases with an environmental contribution.
In our group, we aim to understand whether, and how, environmental inputs regulate chromatin organization. As a model organism, we use the roundworm C. elegans, which allows us to combine genetic manipulations, live imaging and molecular biology assays to study chromatin/environment interactions within cells of an intact animal.
In today´s talk, I will describe our work on investigating the effects of fasting on the spatial organization of the genome.
Le séminaire aura lieu vendredi 8 mars à 11h45 en salle François Jacob (Institut Jacques Monod – 15 rue Hélène Brion 75013 Paris).