Mechanotransduction: from Cell Surface to Nucleus
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How our cells respond to their mechanical environment?
We propose an approach using quantitative fluorescence microscopy and genetic engineering for responses from the molecule to the tissue.
Group Leader: Nicolas Borghi
Directeur de Recherche CNRS
+33 (0)157278041
nicolas.borghi(at)ijm.fr
RESEARCHMEMBERSPUBLICATIONSNEWSJOB
Research Topics:
Quantitative biology and modeling , Cellular dynamics and signaling, Molecular and cellular pathologies
Selected publications:
1: Déjardin T, Carollo PS, Sipieter F, Davidson PM, Seiler C, Cuvelier D, Cadot
B, Sykes C, Gomes ER, Borghi N. Nesprins are mechanotransducers that
discriminate epithelial-mesenchymal transition programs. J Cell Biol. 2020 Oct
5;219(10):e201908036. doi: 10.1083/jcb.201908036. PMID: 32790861; PMCID:
PMC7659719.
2: Davidson PM, Battistella A, Déjardin T, Betz T, Plastino J, Borghi N, Cadot
B, Sykes C. Nesprin-2 accumulates at the front of the nucleus during confined
cell migration. EMBO Rep. 2020 Jul 3;21(7):e49910. doi: 10.15252/embr.201949910.
Epub 2020 May 17. PMID: 32419336; PMCID: PMC7332974.
3: Audugé N, Padilla-Parra S, Tramier M, Borghi N, Coppey-Moisan M. Chromatin
condensation fluctuations rather than steady-state predict chromatin
accessibility. Nucleic Acids Res. 2019 Jul 9;47(12):6184-6194. doi:
10.1093/nar/gkz373. PMID: 31081027; PMCID: PMC6614833.
4: De Pascalis C, Pérez-González C, Seetharaman S, Boëda B, Vianay B, Burute M,
Leduc C, Borghi N, Trepat X, Etienne-Manneville S. Intermediate filaments
control collective migration by restricting traction forces and sustaining cell-
cell contacts. J Cell Biol. 2018 Sep 3;217(9):3031-3044. doi:
10.1083/jcb.201801162. Epub 2018 Jul 6. PMID: 29980627; PMCID: PMC6122997.
5: Gayrard C, Bernaudin C, Déjardin T, Seiler C, Borghi N. Src- and confinement-
dependent FAK activation causes E-cadherin relaxation and β-catenin activity. J
Cell Biol. 2018 Mar 5;217(3):1063-1077. doi: 10.1083/jcb.201706013. Epub 2018
Jan 8. PMID: 29311227; PMCID: PMC5839785.
6: Sarangi BR, Gupta M, Doss BL, Tissot N, Lam F, Mège RM, Borghi N, Ladoux B.
Coordination between Intra- and Extracellular Forces Regulates Focal Adhesion
Dynamics. Nano Lett. 2017 Jan 11;17(1):399-406. doi:
10.1021/acs.nanolett.6b04364. Epub 2016 Dec 23. PMID: 27990827; PMCID:
PMC5423523.
7: Liu Z, Bun P, Audugé N, Coppey-Moisan M, Borghi N. Vinculin head-tail
interaction defines multiple early mechanisms for cell substrate rigidity
sensing. Integr Biol (Camb). 2016 Jun 13;8(6):693-703. doi: 10.1039/c5ib00307e.
Epub 2016 May 11. PMID: 27169142.
8: Lowndes M, Rakshit S, Shafraz O, Borghi N, Harmon RM, Green KJ, Sivasankar S,
Nelson WJ. Different roles of cadherins in the assembly and structural integrity
of the desmosome complex. J Cell Sci. 2014 May 15;127(Pt 10):2339-50. doi:
10.1242/jcs.146316. Epub 2014 Mar 7. PMID: 24610950; PMCID: PMC4021477.
9: Borghi N, Sorokina M, Shcherbakova OG, Weis WI, Pruitt BL, Nelson WJ, and
E-cadherin is under constitutive actomyosin-generated tension that is
increased at cell-cell contacts upon externally applied stretch. Proc Natl Acad
Sci U S A. 2012 Jul 31;109(31):12568-73. doi: 10.1073/pnas.1204390109. Epub 2012
Jul 16. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):19034. PMID:
22802638; PMCID: PMC3411997.
10: Borghi N, Lowndes M, Maruthamuthu V, Gardel ML, Nelson WJ. Regulation of
cell motile behavior by crosstalk between cadherin- and integrin-mediated
adhesions. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13324-9. doi:
10.1073/pnas.1002662107. Epub 2010 Jun 21. PMID: 20566866; PMCID: PMC2922157.