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Borghi Lab – Molecular tension microscopy of the LINC complex in live cells

Actualités, Les dernières publications19 juillet 2022
Félicitations à l'équipe Borghi qui vient de publier dans STAR Protocols un nouveau papier : Molecular tension microscopy of the LINC complex in live cells   Summary We present a protocol to measure the effect of pharmacological treatments on the mechanical tension experienced by nesprins at the cytoplasmic surface of the nuclear envelope of mammalian cells…

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Camadro Lab – AutoClassWeb: a simple web interface for Bayesian clustering of omics data

Les dernières publications12 juillet 2022
Pierre Poulain et Jean-Michel Camadro viennent de publier dans BMC Research Notes un article sur un outil en ligne qu'ils ont développé (AutoClassWeb), qui fournit une interface web simple et facile à utiliser pour le regroupement bayésien avec AutoClass :   AutoClassWeb: a simple web interface for Bayesian clustering of omics data Abstract Objective: Data clustering is…

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Collignon Lab – Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies

Les dernières publications27 juin 2022
Félicitations à l’équipe Collignon pour ce nouvel article publié dans Stem Cell Reports! Dissecting signaling hierarchies in the patterning of the mouse primitive streak using micropatterned EpiLC colonies Summary Embryo studies have established that the patterning of the mouse gastrula depends on a regulatory network in which the WNT, BMP, and NODAL signaling pathways cooperate, but aspects…

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Courtier Lab – Developmental timing of Drosophila pachea pupae is robust to temperature changes

Les dernières publications10 juin 2022
Félicitations à l'équipe Courtier pour ce nouvel article publié dans Journal of Thermal Biology:   Developmental timing of Drosophila pachea pupae is robust to temperature changes   Abstract Rearing temperature is correlated with the timing and speed of development in a wide range of poikiloterm animals that do not regulate their body temperature. However, exceptions exist,…

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Romet-Lemonne / Jégou Lab: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles

Actualités, Les dernières publications24 mai 2022
Félicitations à l'équipe Romet-Lemonne / Jégou pour ce nouvel article publié dans JoVE: Using Microfluidics and Fluorescence Microscopy to Study the Assembly Dynamics of Single Actin Filaments and Bundles Abstract In order to decipher the complex molecular mechanisms that regulate the assembly and disassembly of actin filaments, it is a great asset to monitor individual reactions…

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Ribes Lab – Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs

Actualités, Les dernières publications24 mai 2022
Félicitations à l'équipe Ribes pour ce nouvel article publié dans PLOS Genetics!   Divergent transcriptional and transforming properties of PAX3-FOXO1 and PAX7-FOXO1 paralogs   Abstract The hallmarks of the alveolar subclass of rhabdomyosarcoma are chromosomal translocations that generate chimeric PAX3-FOXO1 or PAX7-FOXO1 transcription factors. Overexpression of either PAX-FOXO1s results in related cell transformation in animal models. Yet, in patients…

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Libri Lab: A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution

Les dernières publications9 mai 2022
Vient de paraitre dans Yeast Functional Genomics  pp 35-55 A Modified Cross-Linking Analysis of cDNAs (CRAC) Protocol for Detecting RNA–Protein Interactions and Transcription at Single-Nucleotide Resolution by: Drice Challal Jessie Colin Tommaso Villa Domenico Libri   Abstract Detecting protein–RNA interactions in vivo is essential for deciphering many important cellular pathways. Several…

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Camadro Lab / ProtéoSeine: Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores

Les dernières publications9 mai 2022
Vient de paraître dans Yeast Functional Genomics  pp 275-292   Quantitative Proteomics in Yeast : From bSLIM and Proteome Discoverer Outputs to Graphical Assessment of the Significance of Protein Quantification Scores By Nicolas Sénécaut Pierre Poulain Laurent Lignières Samuel Terrier Véronique Legros Guillaume Chevreux Gaëlle Lelandais Jean-Michel Camadro

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Pintard Lab: The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry

Les dernières publications9 mai 2022
Un nouvel article publié dans médecine/sciences par l'équipe Pintard : The kiss of life: Aurora A embraces the phosphate of its cofactor Bora to trigger mitotic entry   La plupart des organismes vivants pluricellulaires sont constitués d’un grand nombre de cellules très différentes. À l’exception des gamètes, qui sont le produit d’une division cellulaire particulière (méiose), toutes…

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Duharcourt Lab – Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements

Les dernières publications21 avril 2022
Un nouvel article publié par l’équipe Duharcourt dans Developmental Cell! Paramecium Polycomb repressive complex 2 physically interacts with the small RNA-binding PIWI protein to repress transposable elements   Summary Polycomb repressive complex 2 (PRC2) maintains transcriptionally silent genes in a repressed state via deposition of histone H3K27-trimethyl (me3) marks. PRC2 has also been implicated in silencing transposable elements (TEs), yet how PRC2 is…

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