The Duharcourt Lab published a new article in Nucleic Acids Research: The PIWI-interacting protein Gtsf1 controls the selective degradation of small RNAs in Paramecium   Abstract: Ciliates undergo developmentally programmed genome elimination, in which small RNAs direct the removal of transposable elements (TEs) during the development of the somatic nucleus. Twenty-five nucleotide scanRNAs (scnRNAs) are produced from the entire…

The Romet-Lemonne/Jégou Lab contributed a new article published in PNAS: HIV-1 budding requires cortical actin disassembly by the oxidoreductase MICAL1   Abstract: Many enveloped viruses bud from the plasma membrane that is tightly associated with a dense and thick actin cortex. This actin network represents a significant challenge for membrane deformation and scission, and how it is remodeled…

The Minc Lab published a new method article in Methods in Molecular Biology :  Analysis of Cell Wall Mechanics in Fission Yeast   Abstract: The growth and shape of fungal cells, such as fission yeast, are strongly constrained by the mechanics of their cell wall (CW). The cell wall encases the plasma membrane and defines instantaneous cell shapes…

The Dumont Lab contributed to a new article published in microPublication Biology: Cell type-specific regulation by different cytokinetic pathways in the early embryo Abstract: Cytokinesis, the physical division of one cell into two, is typically assumed to use the same molecular process across animal cells. However, regulation of cell division can vary significantly among different cell types,…

The ProtéoSeine platform contributed to the publication of a new article dans ACS Chemical Biology: Bioorthogonal Monomycolate of Trehalose Disclosed the O-Mycoloylation of Mycoloyltransferases and Other Cell Envelope Proteins in C. glutamicum   Abstract: Protein mycoloylation is a recently identified unusual post-translational modification (PTM) exclusively observed in Mycobacteriales, an order of bacteria that includes several human pathogens. These bacteria…

The Courtier Lab published a new article in Evolutionary Biology: A scenario for an evolutionary selection of ageing Abstract: Signs of ageing become apparent only late in life, after organismal development is finalized. Ageing, most notably, decreases an individual’s fitness. As such, it is most commonly perceived as a non-adaptive force of evolution and considered a…

Isabelle le Parco, and the platform she runs, contributed to the publication of an article in Communications biology: Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation Abstract: Intestinal smooth muscle differentiation is a complex physico-biological process involving several different pathways. Here, we investigate the properties of Ca2+ waves in the developing…

The Veitia lab published a new article in Trends in Genetics : Emerging links between phase separation and transcription factor haploinsufficiency   Abstract: Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency of…

The Greenberg Lab published a new article in Nature structural & Molecular biology: DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency Abstract: In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit the…

The Grange / Geigl Lab published a new article in Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Abstract: Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise location(s)…