Skip to content Skip to footer

Institut Jacques Monod
Close

Ladoux/Mège Lab – The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces

Home publis, News16 September 2022
The Ladoux/Mège Team has just published a new paper in Science Advances: The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces   Abstract Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous…

Read More

Plessis Lab – High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened

Home publis, News12 September 2022
The Plessis Lab has just published a new paper in eLife! High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened Abstract The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures.…

Read More

IJM Seminar – Pierre Nassoy – 07/10/2022

News2 September 2022
Invited by Benoit Ladoux, Pierre Nassoy (UMR 5298 CNRS, Laboratoire de Photonique, Numérique et Nanosciences) will give on October 7th a seminar entitled: Self-assembly and mechanosensing in bloody, nervous, fat or tumoral organoids   BIOF LAB : BIOIMAGING & OPTOFLUIDICS LABORATORY Our lab has developed a microfluidics-assisted technique, the Cellular Capsule Technology (CCT) that enables to…

Read More

IJM Seminar – Morgan Delarue – 30/09/2022

News2 September 2022
Invited by Nicolas Minc, Morgan Delarue (Team MILE, LAAS-CNRS) will give on September 30th a seminar entitled: Cell growth under mechanical pressure   Team MILE, LAAS-CNRS Our research focuses on compressive mechanicalstress: What happens when cells are squished? What are the biological and physical determinants of the response to compression? Is there an evolutionarily conserved response? How does…

Read More

Léon Lab – 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity

Home publis, News1 September 2022
A new paper just published by Léon Lab in PLOS Genetics! 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity   Abstract 2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into 2-deoxyglucose-6-phosphate (2DG6P), it interferes with several metabolic pathways including glycolysis and…

Read More

IJM Seminar – Robert Klose – 20/09/2022

News1 September 2022
Invited by Maxim Greenberg, Rob Klose (Department of Biochemistry, University of Oxford) will give on September 20th a seminar entitled: Understanding how CpG islands regulate gene expression   Epigenetic regulation of chromatin function Every human begins as a single cell that has the instructions, encoded within its DNA and genes, necessary to build a fully functioning human being.…

Read More

IJM Seminar – Stephanie Höhn – 15/09/2022

News1 September 2022
Invited by Hugo Wioland, Stephanie Höhn (Senior Research Associate, University of Cambridge) wiil give on September 15th a seminar entitled: Cut it out - Residual torques in dynamic cellular monolayers   Research How do cells generate the forces that shape our tissues and organs? In developing embryos, its cells move and change their shape in an astoundingly…

Read More