The Veitia team has just published a new paper in Cancer Research : The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors   Abstract Adult-type granulosa cell tumors (AGCT) are the most common type of malignant ovarian sex cord–stromal tumors. Most AGCTs carry the somatic variant c.402C>G (p.C134W) affecting the transcription factor FOXL2.…

The Protoseine Facility has just published a new paper in  Journal of Chromatography B : Capillary liquid chromatography coupled with mass spectrometry for analysis of nanogram protein quantities on a wide-pore superficially porous particle column in top-down proteomics   Abstract In top-down proteomics experiments, intact protein ions are subjected to gas-phase fragmentation for MS analysis without…

The Grange/Geigl team recently published a book chapter i Microbial Environmental Genomics (Part of the Methods in Molecular Biology book series (MIMB,volume 2605) Analysis of Ancient Microbial DNA Abstract The development of next-generation sequencing has led to a breakthrough in the analysis of ancient genomes, and the subsequent genomic analyses of ancient human skeletal remains have…

The Ladoux/Mège Team has just published a new paper in Biomaterials   Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies   Abstract Quantification of skeletal muscle functional contraction is essential to assess the outcomes of therapeutic procedures for neuromuscular disorders. Muscle three-dimensional “Organ-on-chip” models usually require a substantial amount of biological…

The Vervoort Team has just published a new paper in JEZ-B: Molecular and Developmental Evolution: On the hormonal control of posterior regeneration in the annelid Platynereis dumerilii   Abstract Regeneration is the process by which many animals are able to restore lost or injured body parts. After amputation of the posterior part of its body, the annelid Platynereis dumerilii is…

The Ladoux/Mège Team has just published a new paper in Nature Physics:   Mechanical stress driven by rigidity sensing governs epithelial stability Abstract: Epithelia act as barriers against environmental stresses. They are continuously exposed to various mechanical stress and abrasion, which impact epithelial integrity. The impact of the environment on epithelial integrity remains elusive. By culturing epithelial…

The Minc Team has just published a new review in Journal of Cell Science : Mechanobiology of the cell wall – insights from tip-growing plant and fungal cells ABSTRACT The cell wall (CW) is a thin and rigid layer encasing the membrane of all plant and fungal cells. It ensures mechanical integrity by bearing mechanical stresses…

The Veitia team has just published a new paper in Clinical Genetics:   Recurrent missense variants in clonal hematopoiesis-related genes present in the general population   Abstract Clonal hematopoiesis (CH) consists in an abnormal expansion of a hematopoietic stem cell bearing an advantageous somatic variant. A survey of known recurrent somatic missense variants in DNMT3A, SF3B1, SRSF2 and TP53, some of the…

A new paper just published in Cancers : Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Abstract Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR).…

The Wassmann team has just published a new paper in Developmental Cell: Cyclin B3 implements timely vertebrate oocyte arrest for fertilization Summary To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how this arrest is implemented exclusively…