The Gazave lab published a new article in EMBO reports: Multifaceted conserved functions of Notch during post-embryonic neurogenesis in the annelid Platynereis Abstract: Notch signaling is an evolutionarily conserved pathway known to orchestrate neurogenesis by regulating the transition from progenitors to neurons and glia, and by directing neurite outgrowth and axon guidance in many species. Although extensively studied…

The Duharcourt  Lab published a new article in Genome Biology: A H3K27me3 reader complex couples H3K27me3 accumulation to nascent transcription of transposable elements in Paramecium Abstract: Backgroud The ability to deposit histone H3K27-trimethyl (me3) marks is essential for transcriptional repression by Polycomb Repressive Complex 2 (PRC2). This is largely attributed to Polycomb repressive complex 1 (PRC1), whose…

The Wassmann Lab published a review in Chromosome Research: Decoding Cdk1 control: from mitotic thresholds to meiotic specificity Abstract: The eukaryotic cell cycle is one of the most fundamental biological processes, ensuring the accurate duplication and segregation of the genome during mitosis. Decades of research across model systems have shown that this process is orchestrated by a…

The Romet-Lemonne / Jégou Lab contributed to the publication of a new article in Science Advances: Mechanisms of CARMIL dimerization, autoinhibition, and capping protein binding Abtract: Capping protein (CP) regulates actin-based motility by blocking monomer exchange at the filament barbed end. Several proteins, including CARMIL, bind CP and allosterically weaken its affinity for the barbed end. CARMIL…

The former Camadro Lab and the ProtéoSeine platform contributed to the publication of a new article in Cell Reports Medicine: SIRT1 mediates brain metabolic and developmental consequences of methionine synthase deficiency in inborn errors of cobalamin metabolism Abstract: Inborn errors of vitamin B12 metabolism (IECM) resulting from impaired methionine synthase (MTR) activity cause severe cognitive and neurological…

The Ladoux/Mège Lab  contributed to the publication of a new article in Materials Horizons: Thermal-driven H-bond reconfiguration for bioinspired high-strength anisotropic supramolecular hydrogels Astract: Natural anisotropic tissues, such as tendons and cartilages, achieve remarkable mechanical properties and various biofunctions through oriented hierarchical structures. Inspired from organisms, we develop a synergistic molecular and structural engineering technique based on…

The Minc published a new article inMolecular Biology of the Cell: A cross-species analysis of cell wall mechanosensors Abstract: The Cell Wall (CW) protects fungal cells from various challenges making its integrity essential for cell survival. CW integrity is monitored by transmembrane sensors that activate effectors to promote CW synthesis in response to injuries. Sensors of the…

The Léon Lab contributed to the publication of a new article in Journal of Cell Biology: Ist2 is a phospholipid scramblase that links lipid transport at the ER to organelle homeostasis Abstract: Lipid scramblases allow passive flip-flop of phospholipids between bilayer leaflets, thereby promoting membrane symmetry. At the endoplasmic reticulum (ER), where phospholipid synthesis is restricted to…

The Pintard Lab contributed to the publication of a new article in Journal of Biological Chemistry: The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation Abstract: SETD2 is the primary methyltransferase responsible for generating H3K36me3, an epigenetic mark that is essential for transcriptional regulation and chromatin integrity. SETD2 mutations are frequently observed in…

The Konstantinides Lab published a new article in Developmental Biology: Gene expression cartography of a developing neuronal structure Abstract: Brains are complex structures comprising thousands to billions of neurons that belong to thousands of different neuronal types. These neurons often come from different progenitor domains and have very diverse developmental histories, yet they need to find…