L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Structural & Molecular biology : DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Résumé : As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the…

L'équipe Camadro et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans eBioMedicine : Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Résumé : Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types…

L'équipe Raote a contribué à la publication d'un nouvel article dans PNAS : A model for collagen secretion by intercompartmental continuities   Résumé : Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated vesicle of 60 nm…

L'équipe Balavoine a récemment publié un nouvel article dans Plos One : Fast cycling culture of the annelid model Platynereis dumerilii   Résumé : Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The…

L'équipe Ribes a publié un nouvel article dans Emerging topics in life sciences : Stem cell-derived models of spinal neurulation   Résumé : This review is the fruit of an enriching collaboration with my thesis supervisors Vanessa Ribes and Stéphane Nedelec (Institut du Fer à Moulin), along with Martin Catala (Institut de Biologie Paris Seine) and Mikaëlle Bocel…

L'équipe Courtier a récemment publié un nouvel article dans Plos one : Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries   Résumé : During COVID-19 pandemic several public health measures were implemented by diverse countries to reduce the risk of COVID-19, including social distancing. Here we collected the minimal distance recommended by each…

L'équipe Léon a contribué à la publication d'un article dans Molecular Cell : Ubiquiton - An inducible, linkage-specific polyubiquitylation tool   Résumé : The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools to induce linkage-specific polyubiquitylation of…