L'équipe Ladoux / Mège a récemment contribué à la publication d'un nouvel article dans Nature Cell biology : A mechanosensitive caveolae–invadosome interplay drives matrix remodelling for cancer cell invasion Résumé : Invadosomes and caveolae are mechanosensitive structures that are implicated in metastasis. Here, we describe a unique juxtaposition of caveola clusters and matrix degradative invadosomes at…

L'équipe Camadro a récemment contribué à la publication d'un nouvel article dans Briefing in Bioinformatics : The five pillars of computational reproducibility: bioinformatics and beyond   Résumé : Computational reproducibility is a simple premise in theory, but is difficult to achieve in practice. Building upon past efforts and proposals to maximize reproducibility and rigor in bioinformatics, we present a…

L'équipe Courtier a récemment publié un nouvel article dans Current Opinion in Insect Science : The loci of insect phenotypic evolution   Résumé : Insects are important elements of terrestrial ecosystems because they pollinate plants, destroy crops, transmit diseases to livestock and humans, and are important components of food chains. Here, I used Gephebase, a manually curated database…

L'équipe Grange/Geigl a publié un nouvel article dans Nature Ecology and Evolution :  Genome sequences of 36-37,000 year-old modern humans at Buran-Kaya III in Crimea Deux génomes de 36-37 000 ans de Crimée éclairent les premières implantations réussies des Humains modernes en Europe et l’émergence du Gravettien L’implantation des Humains en Eurasie après leur sortie d’Afrique fut un…

L'équipe Gazave a récemment publié un nouvel article dans BMC Genomics : Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii Résumé : Background Restorative regeneration, the capacity to reform a lost body part following amputation or injury, is an important and still poorly understood process in animals. Annelids, or segmented worms, show amazing regenerative capabilities,…

L'équipe Palancade a récemment publié un nouvel article dans Nature communications : A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes   Résumé : Nuclear pore complexes (NPCs) have increasingly recognized interactions with the genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By combining genome-wide approaches with live…

L'équipe Ladoux/Mège a contribué à la publication d'un article dans Nature Communications :  Hexanematic crossover in epithelial monolayers depends on cell adhesion and cell density Résumé : Changes in tissue geometry during developmental processes are associated with collective migration of cells. Recent experimental and numerical results suggest that these changes could leverage on the coexistence of nematic…

L'équipe Conduit et l'équipe Guichet ont récemment publié dans Journal of Cell Biology : Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes Résumé : Microtubule nucleation is mediated by γ-tubulin ring complexes (γ-TuRCs). In most eukaryotes, a GCP4/5/4/6 “core” complex promotes γ-tubulin small complex (γ-TuSC) association to generate cytosolic γ-TuRCs. Unlike γ-TuSCs, however,…

L'équipe Azimzadeh a récemment publié dans Current Biology : Evolution: The ancient history of cilia assembly regulation Résumé : A new study identifies a conserved regulatory mechanism for cilia assembly in the closest unicellular relatives of animals, suggesting that this mechanism was already present in a common unicellular ancestor and was repurposed during the transition to multicellularity.

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nucleic Acids Research : A genetic screen identifies BEND3 as a regulator of bivalent gene expression and global DNA methylation   Résumé :  Epigenetic mechanisms are essential to establish and safeguard cellular identities in mammals. They dynamically regulate the expression of genes, transposable elements and higher-order chromatin structures.…