Institut Jacques Monod
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Mechanisms of Meiosis – MOM

Katja WASSMANN

Sexual reproduction requires the generation of haploid gametes through two meiotic divisions, named meiosis I and II. In mammals and especially humans, female gametogenesis is highly error prone, leading to the generation of oocytes harbouring the wrong chromosome content.

Projects in my group aim at dissecting the molecular mechanisms underlying the two meiotic divisions with a focus on oocytes, to understand how errors occur. The central question we study deals with the issue of how meiosis I-specific events are executed only in meiosis I, and those of meiosis II only in meiosis II.

Keywords: Meiosis, Oocytes, Cohesin, Phosphoproteome, Cell cycle, Aneuploidy

+33 (0)157278148    katja.wassmann(at)ijm.fr    https://www.researchgate.net/profile/Katja-Wassmann

Research

  • In meiosis, key events need to happen in the correct order, and at the right time, otherwise the generation of healthy gametes is compromised. In our projects we focus on elucidating the underlying regulatory mechanisms of meiosis-specific events with a special focus on oocytes, to gain insights into how these events are put into place in the correct developmental context, e.g. meiosis I or II.Specific features of the meiotic divisions (meiosis I and II):
    • Homologous chromosomes (each consisting of two sister chromatids) are paired and segregated in meiosis I, and sister chromatids in meiosis II
    • Kinetochores (the attachment sites for the bipolar spindle) of the two paired sister chromatids are co-oriented to the same pole in meiosis I, and bioriented to opposite poles in meiosis II (named mono- and bipolar orientation or attachment, respectively).
    • The cohesin complex, which is holding sister chromatids together, is removed in a step-wise manner, from chromosome arms in meiosis I, and the centromere region in meiosis II.
    • Transition from meiosis I into meiosis II occurs without intervening S-phase

     

    An additional specificity of vertebrate oocytes is the requirement to implement two cell cycle arrests: One before entry into meiosis I, in prophase I, which lasts decades in humans; a second arrest in metaphase of meiosis II, called CSF-arrest, to await fertilization.

     

    The overarching question of our projects is the following:

    How are the two successive meiotic divisions implemented without mixing up meiosis I and meiosis II specific events?

 

         Our research questions:

 

  • Model systems we use in the lab:Projects1) Meiotic cell cycle control, Cdk-Cyclin specificities and threshold levelsWe think that a global view on mitotic kinase substrate phosphorylation and dephosphorylation, to dissect common principles governing the meiotic divisions, will be key to understand how transition from meiosis I to meiosis II is regulated. Currently we use budding yeast as a model system for this question, to gain insights into this special cell cycle transition in a simple model system, removing an additional layer of complexity that can be expected in oocytes.Additionally, we study Cyclin specificity and Cdk threshold levels for implementing meiosis-specific cell cycle events, using frog and mouse oocytes. We have discovered that at least two M-phase cyclins- Cyclin A2 and B3- occupy specific roles that are not redundant with other cyclins. Both cyclins have functions related to ordering meiosis I and meiosis II-specific events. Our projects aim at identifying specific substrates of these cyclins, and the molecular mechanisms underlying their meiosis-specific roles.2) Step-wise cohesin removal in mammalian oocytes 

    Step-wise cohesin removal is brought about by protection of the centromeric cohesin subunit Rec8 from cleavage by the protease Separase at the centromere region in meiosis I, and by removing this protection before sister chromatid segregation in meiosis II. Protection is due to the recruitment of Sgo2, which brings the phosphatase PP2A to the centromere to maintain Rec8 there in a dephosphorylated state. However, several open questions are remaining, starting with the question of how Separase activity is controlled to get inhibited and activated twice, and how proteins involved in protection do so in meiosis I, but not meiosis II, and only in the centromere region.

     

    3) Kinetochore attachments and checkpoint controls in mammalian oocytes

     

    Again related to our main question of how meiosis I and meiosis II events are implemented at the correct time, we want to understand how checkpoints can recognize the correct attachments in their proper context, e.g. monopolar attachments to segregate chromosomes in meiosis I, and bipolar attachments in meiosis II to segregate sister chromatids. Additionally we address whether both kinetochores are functional in meiosis I when they are mono-oriented and fused.

 

 

Members

Direction

  • Louise ABBOU, Ingénieur d études en biologie moléculaire, DUHARCOURT LAB
    +33 (0)1 57 27 80 09, room 554B
  • Sandrine ADIBA, Responsable plateforme, PFT/enSCORE
    +33 (0)1 57 27 80 62, room 342B

Support staff

  • Dina AL ABYAD, Postdoctorante, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Véronique ALBANESE, Chercheur, LEON LAB
    +33 (0)1 57 27 80 50, room 355B
  • Marin ALRIC, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22
  • Nathalie ALVAREZ, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 82 95, room RB30B
  • Marine ALVES, Ingénieur en biologie, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 04, room 244B
  • Lucas ANGER, Doctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Maria Isabel ARJONA HIDALGO, Postdoctorante, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Gregory ARKOWITZ, Doctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Manon ARNAUD, Ingénieure en biologie, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Françoise AUCHERE, Enseignant-chercheur, CAMADRO LAB
    +33 (0)1 57 27 80 28, room 390B
  • Nicolas AUDUGE, Ingénieur en microscopie photonique, BORGHI LAB
    +33 (0)1 57 27 80 42, room 302B
  • Juliette AZIMZADEH, Chercheur, AZIMZADEH LAB
    +33 (0)1 57 27 81 13, room 544B
  • Macy BABOCH, RAOTE LAB
  • Anna BABOUR, Chercheur, PALANCADE LAB
    +33 (0)1 57 27 80 39, room 354B
  • Loeiza BADUEL, Technicienne en biologie, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 293B
  • Camille BAGES, Doctorante, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 56, room 255B
  • Thomas BALAN, Doctorant, DUHARCOURT LAB
    +33 (0)1 57 27 80 00, room 554B
  • Mariia BALATSKAIA, Postdoctorante, BORGHI LAB
    +33 (0)1 57 27 80 41, room 302B
  • Guillaume BALAVOINE, Chercheur, BALAVOINE LAB
    +33 (0)1 57 27 80 02, room 154B
  • Giuseppe BALDACCI, Enseignant-chercheur émérite, CADORET LAB
    +33 (0)1 57 27 81 41, room RB05B
  • Alberto BALLIN, Doctorant, LEON LAB
    +33 (0)1 57 27 80 50, room 355B
  • Lydia BALMY, Assistante ressources humaines, SUPPORT/RH
    +33 (0)1 57 27 82 93, room RB02B
  • Nor-Eddine BAOUZ, Responsable magasin, SUPPORT/MAGASIN
    +33 (0)1 57 27 81 67, room S27A
  • Theo BARET, Ingénieur de recherche en bioinformatique génomique, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Xavier BAUDIN, Responsable microscopie photonique, PFT/IMAGOSEINE/PHOTONIQUE
    +33 (0)1 57 27 81 56, room RH20B6
  • Julie BEAUCOUSIN, JACKSON/VERBAVATZ LAB
    +33 (0)157278005, room 244B
  • Georges BEAUD, Chercheur émérite, DIRECTION
  • Isabelle BECAM, Enseignant-chercheur, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Florian BELLETERRE, Soigneur-animalier, PFT/ANIMALERIE
    +33 (0)1 57 27 81 86, room 514A
  • Laura BELLUTTI, Postdoctorante, DUMONT LAB
    +33 (0)1 57 27 80 49, room 402B
  • Frédéric BERNARD, Enseignant-chercheur, GUICHET LAB
    +33 (0)1 57 27 80 77, room 422B
  • Amélie BESOMBES, Doctorante, PRIOLEAU LAB
    room 520B
  • Savandara BESSE, Postdoctorante, COURTIER LAB
    +33 (0)1 57 27 80 43, room 416B
  • Ingrid BILLAULT-CHAUMARTIN, Postdoctorante, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Téo BITAILLE, Technicien en biologie, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 92, room 425B
  • Mikaelle BOCEL, Ingénieure de plateforme, PFT/enSCORE
    +33 (0)1 57 27 80 62, room 342B
  • Pierre BONNESOEUR, Ingénieur en biologie, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Nicolas BORGHI, Chercheur, BORGHI LAB
    +33 (0)1 57 27 80 41, room 302B
  • Camille BOUCHER, Ingénieure en biologie, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Kamal BOUHALI, Responsable plateforme, PFT/enSCORE
    +33 (0)1 57 27 80 62, room 342B
  • Meriem BOUMENDJEL, Doctorante, AZIMZADEH LAB
    +33 (0)1 57 27 81 12, room 544B
  • Charlotte BRANCAZ, Chargée de communication, SUPPORT/APPUI
    +33 (0)1 57 27 71 35, room RB07B
  • Raphael BRAUD-MUSSI, Ingénieur bases de données et analyse d images, PFT/IMAGOSEINE/PHOTONIQUE
    +33 (0)1 57 27 81 56, room RH20B6
  • Lina-Marie BRIU, Doctorante, CADORET LAB
    +33 (0)1 57 27 80 74, room 254B
  • Veronique BRODU, Chercheur, GUICHET LAB
    +33 (0)1 57 27 80 78, room 422B
  • Sylvain BRUN, Enseignant-chercheur, GUICHET LAB
    +33 (0)1 57 27 80 87, room 422B
  • Brigitte BUENDIA, Chercheur, DOYE LAB
    +33 (0)1 57 27 80 60, room 344B
  • Eulalie BUFFIN, Enseignant-chercheur, WASSMANN LAB
    +33 (0)1 57 27 80 35, room 322B
  • Sandrine CABURET, Enseignant-chercheur, VEITIA LAB
    +33 (0)1 57 27 81 14, room 526B
  • Jean-Charles CADORET, Enseignant-chercheur, CADORET LAB
    +33 (0)1 57 27 80 74, room 254B
  • Jean-Michel CAMADRO, Chercheur, CAMADRO LAB
    +33 (0)1 57 27 80 29, room 383B
  • Sandra CARVALHO, Doctorante, GUICHET LAB
    +33 (0)1 57 27 80 76, room 422B
  • Karine CASIER, PALANCADE LAB
    +33 (0)1 57 27 80 39, room 354B
  • Marie Helène CATALA-DIAZ, Adjointe au responsable Gestion & Finance, SUPPORT/GESTION
    +33 (0)1 57 27 82 98, room RB30B
  • Olivia CHARMANT, Postdoctorante, DUHARCOURT LAB
    +33 (0)1 57 27 80 09, room 554B
  • Kenza CHERIET, Doctorante, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Guillaume CHEVREUX, Responsable plateforme ProtéoSeine, PFT/PROTEOSEINE
    +33 (0)1 57 27 81 19, room 657B
  • Ranjith Kumar CHILUPURI, Doctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Szymon CHOMICZEWSKI, PINTARD LAB
  • Adria CHORRO SATORRA, Doctorant, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Despoina Maria CHOUSIANITI, VEITIA LAB
    +33 (0)1 57 27 81 16, room 526B
  • Damien CLADIERE, Ingénieur en biologie, WASSMANN LAB
    +33 (0)1 57 27 80 66, room 322B
  • Sandra CLARET, Enseignant-chercheur, GUICHET LAB
    +33 (0)1 57 27 80 77, room 422B
  • Yves CLEMENT, Enseignant-chercheur, GAZAVE LAB
    +33 (0)1 57 27 80 03, room 283B
  • Victor COCHARD, Ingénieur en analyse protéomique, PFT/PROTEOSEINE
    +33 (0)1 57 27 81 82, room 657B
  • Jerome COLLIGNON, Chercheur, COLLIGNON LAB
    +33 (0)1 57 27 81 08, room 502B
  • Paul CONDUIT, Chercheur, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Maïté COPPEY, Chercheur émérite, BORGHI LAB
    +33 (0)1 57 27 80 45, room 302B
  • Thibault CORNELOUP, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Virginie COURTIER, Chercheur, COURTIER LAB
    +33 (0)1 57 27 80 43, room 416B
  • Joseph D ALESSANDRO, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 48, room 142B
  • Tien DANG, Ingénieure en biologie, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 68, room 142B
  • Angelique DAUVIN, Soigneur-animalier, PFT/ANIMALERIE
    +33 (0)1 57 27 81 85, room 514A
  • Angélique DAVID, Doctorante, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Simon DE BECO, Enseignant-chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Arthur DECLERCK, PFT/ANIMALERIE
    +33 (0)1 57 27 81 77, room 514A
  • Lucas DENIS, RIBES LAB
    +33 (0)1 57 27 81 93
  • Serge DMITRIEFF, Chercheur, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Caroline DONCARLI, Ingénieure en biologie, PRIOLEAU LAB
    +33 (0)1 57 27 81 24, room 520B
  • Valerie DOYE, Chercheur, DOYE LAB
    +33 (0)1 57 27 81 39, room RB08B
  • Eva DRABIK BLERVAQUE, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 82 94, room RB30B
  • Sushil DUBEY, Postdoctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Claire DUGAST, Chercheur, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Sandra DUHARCOURT, Chercheur, DUHARCOURT LAB
    +33 (0)1 57 27 80 09, room 554B
  • Julien DUMONT, Chercheur, DUMONT LAB
    +33 (0)1 57 27 80 49, room 402B
  • Aude-Isabelle DUPRE, Chercheur, WASSMANN LAB
    +33 (0)1 57 27 80 35, room 322B
  • Catherine DURIEU, Ingénieure en microscopie électronique, PFT/IMAGOSEINE/ELECTRONIQUE
    +33 (0)1 57 27 81 58, room RH20B7
  • Annie DUTRIAUX, Ingénieure en biologie, COLLIGNON LAB
    +33 (0)1 57 27 81 10, room 502B
  • Jelena DZAKULA, CONDUIT LAB
    room 457B
  • Joachim EKOKA, GUICHET LAB
  • Samih EL AARAJ, WASSMANN LAB
    +33 (0)1 57 27 80 66
  • Youssef EL HACHEM, COURTIER LAB
  • Omar EL HAMOUI, Postdoctorant, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Safia EL JAILANI, Doctorante, WASSMANN LAB
    +33 (0)1 57 27 80 66, room 322B
  • Layla EL MOSSADEQ, Doctorante, DUMONT LAB
    +33 (0)1 57 27 80 47, room 402B
  • Abir ELFARKOUCHI, Doctorante, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Marc Antoine FARDIN, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Fabien FAUCHEREAU, Enseignant-chercheur, GRANGE/GEIGL LAB
    +33 (0)1 57 27 81 29, room 583B
  • Jean-Luc FERAT, Enseignant-chercheur, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Konstantina FILIPPOPOULOU, Chercheur, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Domenico FLAGIELLO, Enseignant-chercheur, COLLIGNON LAB
    +33 (0)1 57 27 80 86, room 502B
  • Laurent GAICHET, Responsable service technique, SUPPORT/TECHNIQUE
    +33 (0)1 57 27 81 63, room S19A
  • Futura GATTOBIGIO, Doctorante, COLLIGNON LAB
    +33 (0)1 57 27 81 10, room 502B
  • Catherine GAUCHER, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 81 34, room RB30B
  • Eve GAZAVE, Chercheur, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 290B
  • Eva-Maria GEIGL, Chercheur, GRANGE/GEIGL LAB
    +33 (0)1 57 27 81 32, room 583B
  • Thomas GERMIER, Postdoctorant, BORGHI LAB
    +33 (0)1 57 27 80 41, room 302B
  • Alison GERVAIS, Ingénieure en biochimie, DUMONT LAB
    +33 (0)1 57 27 80 49, room 402B
  • Manon GERVAIS, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Nabila GHAIB, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 290B
  • Foad GHASEMI, Postdoctorant, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Pascale GILARDI HEBENSTREIT, Chercheur, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Marina GIOVANNETTI, DUHARCOURT LAB
    +33 (0)157278009, room 554B
  • Philippe GIRARD, Enseignant-chercheur, BORGHI LAB
    +33 (0)1 57 27 80 42, room 302B
  • Coralie GONCALVES PEREIRA PERRUCA, Assistante-ingénieure en biologie, PALANCADE LAB
    +33 (0)1 57 27 80 38, room 354B
  • Thierry GRANGE, Chercheur, GRANGE/GEIGL LAB
    +33 (0)1 57 27 81 29, room 583B
  • Maxim GREENBERG, Chercheur, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Estelle GUENARD, WASSMANN LAB
  • Bérengère GUICHARD, Ingénieur en biologie, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Antoine GUICHET, Chercheur, GUICHET LAB
    +33 (0)1 57 27 80 76, room 422B
  • Amandine HECQUET, ROMET-LEMONNE/JEGOU LAB
    +33 (0)157278013
  • Mélina HEUZE, Enseignant-chercheur, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 05, room 244B
  • Theaud HEZEZ, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Isabel Maria HOLGUERA LOPEZ, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Stephane HOYEZ, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 82 99, room RB30B
  • Cecile HU, CONDUIT LAB
    room 457B
  • Elisavet ILIOPOULOU, Doctorante, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Emilio Valente IMAD, COURTIER LAB
    +33 (0)1 57 27 80 43, room 416B
  • Catherine JACKSON, Chercheur, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 04, room 244B
  • Xavier JEANNIN, Ingénieur informaticien, SUPPORT/INFORMATIQUE
    +33 (0)1 57 27 81 49, room RB22B
  • Antoine JEGOU, Chercheur, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Pan JIANG, Postdoctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Nicolas JOLY, Chercheur, PINTARD LAB
    +33 (0)1 57 27 80 92, room 483B
  • Adam JOUNI, ROMET-LEMONNE/JEGOU LAB
    +33 (0)157278013
  • Zoe KACHANER, GUICHET LAB
  • Satish KAILASAM MANI, Postdoctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Roger KARESS, Chercheur émérite, DOYE LAB
    +33 (0)1 57 27 80 95, room 344B
  • Inaara KASSAMALY, Doctorante, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Pierre KERNER, Enseignant-chercheur, GAZAVE LAB
    +33 (0)1 57 27 20 24, room 283B
  • Amir KHOSRAVANIZADEH, Postdoctorant, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Leticia KOCH LERNER, Enseignant-chercheur, DUHARCOURT LAB
    +33 (0)1 57 27 80 09, room 554B
  • Nikolaos KONSTANTINIDIS, Chercheur, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Wouter KOOLS, Ingénieur en biologie, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Gabriel KRASOVEC, Postdoctorant, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 290B
  • Alfred LACHAUD, Technicien, SUPPORT/TECHNIQUE
    +33 (0)1 57 27 81 66, room S15A
  • Hugo LACHUER, Postdoctorant, BORGHI LAB
    +33 (0)1 57 27 80 41, room 302B
  • Benoit LADOUX, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Alexis LALOUETTE, Enseignant-chercheur, COURTIER LAB
    +33 (0)1 57 27 80 83, room 416B
  • Rémi LE BORGNE, Responsable microscopie électronique, PFT/IMAGOSEINE/ELECTRONIQUE
    +33 (0)1 57 27 81 58, room RH20B7
  • Isabelle LE PARCO, Responsable plateforme animalerie, PFT/ANIMALERIE
    +33 (0)1 57 27 81 77, room 514A
  • Cécile LEDUC, Chercheur, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Bérangère LEGOIS, Technicien en biologie, VEITIA LAB
    +33 (0)1 57 27 80 81, room 526B
  • Veronique LEGROS, Ingénieure en protéomique, PFT/PROTEOSEINE
    +33 (0)1 57 27 81 82, room 657B
  • Sebastien LEON, Chercheur, LEON LAB
    +33 (0)1 57 27 80 57, room 355B
  • Jean-Antoine LEPESANT, Chercheur émérite, GUICHET LAB
    +33 (0)1 57 27 80 78, room 422B
  • Marie LEY, Postdoctorante, PFT/PROTEOSEINE
    +33 (0)1 57 27 81 19, room 657B
  • Priscillia LHOUMAUD, Chercheur, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Jonathan LOPEZ ARNAIZ, Magasinier, SUPPORT/MAGASIN
    +33 (0)1 57 27 81 67, room S27A
  • Jean-Noel LORENZI, Ingénieur en biologie, COURTIER LAB
    +33 (0)1 57 27 80 83, room 416B
  • Nicolas MACAISNE, Postdoctorant, DUMONT LAB
    +33 (0)1 57 27 80 47, room 402B
  • Soilihi MADI ALI, Préparateur en biologie, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 83, room 252B
  • Ludovic MAINGAULT, Soigneur-animalier, PFT/ANIMALERIE
    +33 (0)1 57 27 81 86, room 514A
  • Marianne MALARTRE, Enseignant-chercheur, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Martine MALET, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 80 91, room RB30B
  • Charlotte MALLART, Postdoctorante, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Léa MAMMRI, Ingénieure en biologie, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Juliette MANDELBROJT, Doctorante, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Raphael MANGIONE, Doctorant, PALANCADE LAB
    +33 (0)1 57 27 80 38, room 354B
  • Elyn MANSOUR ROBIC, MINC LAB
    +33 (0)157278052, room 316B
  • Agathe MARCHAND, Soigneur-animalier, PFT/ANIMALERIE
    +33 (0)1 57 27 81 87, room 514A
  • Joel MARCHAND, Responsable Informatique & Réseaux, SUPPORT/INFORMATIQUE
    +33 (0)1 57 27 81 49, room RB22B
  • Kathrin MARHEINEKE, Chercheur, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Chrystelle MARIC ANTOINAT, Chercheur, CADORET LAB
    +33 (0)1 57 27 80 74, room 254B
  • Emmanuelle MARJAULT, Stagiaire, WASSMANN LAB
    +33 (0)1 57 27 80 66, room 322B
  • Lesley Caitlin MARTIN, Doctorante, GRANGE/GEIGL LAB
    +33 (0)1 57 27 81 29, room 583B
  • Paula MARTIN GIL, Ingénieur en biologie, AZIMZADEH LAB
    +33 (0)1 57 27 81 13, room 544B
  • Rachel MARTINDALE, Stagiaire, DOYE LAB
    +33 (0)1 57 27 80 62, room 342B
  • Aurélie MASSON, Doctorante, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Gilliane MATON, Enseignant-chercheur, DUMONT LAB
    +33 (0)1 57 27 80 47, room 402B
  • Vincent MAUPU-MASSAMBA, Préparateur en biologie, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 92, room 592B
  • Rene-Marc MEGE, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Akila MERAH, Postdoctorante, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Samia MILED, ATER, LEON LAB
    +33 (0)1 57 27 80 57, room 355B
  • Alexandre MILLER, Technicien, SUPPORT/TECHNIQUE
    +33 (0)1 57 27 81 66, room S15A
  • Nicolas MINC, Chercheur, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Camil MIRDASS, Doctorant, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Myrto MITLETTON, KONSTANTINIDES LAB
    +33 (0)157278022
  • Mohamed MLIH, Ingénieur en biologie, PALANCADE LAB
    +33 (0)1 57 27 80 38, room 354B
  • Nicolas MOISAN, Ingénieur en microscopie photonique, PFT/IMAGOSEINE/PHOTONIQUE
    +33 (0)1 57 27 81 56, room RH20B6
  • Stephanie MORCHOISNE, Ingénieure en biologie, DOYE LAB
    +33 (0)1 57 27 80 61, room 342B
  • Ludovic MOUSSERON, Doctorant, VEITIA LAB
    +33 (0)1 57 27 81 16, room 526B
  • Sephora MUHAMMAD, LEON LAB
    +33 (0)1 57 27 80 50, room 355B
  • Celia Maria MUNICIO DIAZ, Ingénieure en biologie, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Romain NAILLON, Ingénieur en photonique, PFT/IMAGOSEINE/PHOTONIQUE
    +33 (0)1 57 27 81 56, room RH20B6
  • Sunitha NARASIMHA, Ingénieure en biologie, COURTIER LAB
    +33 (0)1 57 27 80 83, room 416B
  • Marie NOGUEIRA DE BARROS, Responsable Gestion et Finance, SUPPORT/GESTION
    +33 (0)1 57 27 81 44, room RB30B
  • Aude NOMMICK, Postdoctorante, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Anna NOVAK VANCLOVA, Postdoctorante, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 04, room 244B
  • Isabelle NUEZ, Ingénieure en biologie, COURTIER LAB
    +33 (0)1 57 27 80 75, room 416B
  • Philippine ORMANCEY, Assistante-ingénieure en biologie, PINTARD LAB
    +33 (0)1 57 27 80 92, room 483B
  • Batool OSSAREH-NAZARI, Ingénieure de recherche, PINTARD LAB
    +33 (0)1 57 27 80 92, room 490B
  • Christie OUADDI, Préparatrice en biologie, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 83, room 325B
  • Rebecca PAGÈS, Assistante-ingénieure en biologie, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Benoit PALANCADE, Chercheur, PALANCADE LAB
    +33 (0)1 57 27 80 39, room 354B
  • Lilian PATY, Doctorant, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Sudheer Kumar PENETI, Doctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Emilie PERCHULIN, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 80 01, room RB30B
  • Thammitage Priyan Jayadewa PERERA, Technicien informatique, SUPPORT/INFORMATIQUE
    +33 (0)1 57 27 81 49, room RB22B
  • Clarisse PICARD, Technicienne en biologie, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 92, room 425B
  • Brice PICHARD, Doctorant, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 293B
  • Anais PILLAN, Doctorante, PINTARD LAB
    +33 (0)1 57 27 80 92, room 483B
  • Lionel PINTARD, Chercheur, PINTARD LAB
    +33 (0)1 57 27 80 89, room 490B
  • Anne PLESSIS, Enseignant-chercheur, DIRECTION
    +33 (0)1 57 27 80 44, room RB07B
  • Irem POLAT, Doctorante, WASSMANN LAB
    +33 (0)1 57 27 80 66, room 322B
  • Ona PRAT PLANAS, Doctorante, DOYE LAB
    +33 (0)1 57 27 80 62, room 342B
  • Antoine PREVEL, BALAVOINE LAB
  • Marie-Noelle PRIOLEAU, Chercheur, PRIOLEAU LAB
    +33 (0)1 57 27 81 02, room 520B
  • Véronique PROUX-GILLARDEAUX, Chercheur, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 81 06, room 244B
  • Daniel QUINTAS, Soigneur-animalier, PFT/ANIMALERIE
    +33 (0)1 57 27 81 87, room 514A
  • Naoual RAKIB, Gestionnaire, SUPPORT/GESTION
    +33 (0)1 57 27 81 96, room RB30B
  • Ishier RAOTE, Chercheur, RAOTE LAB
    +33 (0)1 57 27 81 45, room 285B
  • Yannis REIGNIER, Doctorant, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Michaël RERA, Chercheur, COURTIER LAB
    +33 (0)1 57 27 80 83, room 416B
  • Vanessa RIBES, Chercheur, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Julien RICHARD ALBERT, Postdoctorant, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Rebekah RICQUEBOURG, Doctorante, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Thomas RIOS, Ingénieur en microscopie photonique, PFT/IMAGOSEINE/PHOTONIQUE
    +33 (0)1 57 27 81 56, room RH20B6
  • Nicolas ROBERT, GUICHET LAB
    +33 (0)1 57 27 80 77, room 422B
  • Fanny ROLAND-GOSSELIN, Doctorante, GUICHET LAB
    +33 (0)1 57 27 80 77, room 422B
  • Guillaume ROMET-LEMONNE, Chercheur, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Robin RONDON, Doctorant, RIBES LAB
    +33 (0)1 57 27 81 93, room 555B
  • Carine ROSSE, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Ludivine ROUMBO, Doctorante, PINTARD LAB
    +33 (0)1 57 27 80 89, room 490B
  • Cristina RUBIO RAMON, Ingénieure en biologie, DUHARCOURT LAB
    +33 (0)1 57 27 80 09, room 554B
  • Laura RUIZ, Ingénieure en biologie, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Jérémy SALLE, Chercheur, MINC LAB
    +33 (0)1 57 27 80 52, room 316B
  • Matthieu SANIAL, Assistant ingénieur en biologie, LEON LAB
    +33 (0)1 57 27 80 50, room 355B
  • Thawsika SASIKUMAR, COLLIGNON LAB
    +33 (0)157278110
  • Margherita SCARPA, Ingénieure en biologie, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Andreas SCHONIT, Doctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Valerie SERRE, Enseignant-chercheur, CAMADRO LAB
    +33 (0)1 57 27 80 28, room 390B
  • Yuan SHEN, Postdoctorant, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 68, room 142B
  • Joël SILBER, Enseignant-chercheur émérite, VEITIA LAB
    +33 (0)1 57 27 81 16, room 526B
  • Félix SIMON, Postdoctorant en évolution et développement des systèmes, KONSTANTINIDES LAB
    +33 (0)1 57 27 80 22, room 442B
  • Gaël SIMON, Doctorant, COLLIGNON LAB
    +33 (0)1 57 27 81 09, room 502B
  • Kévin SOLLIER, BORGHI LAB
    +33 (0)1 57 27 80 41, room 302B
  • Manon STEPANOFF, GRANGE/GEIGL LAB
    +33 (0)1 57 27 81 29, room 583B
  • Leonardo TADINI, KONSTANTINIDES LAB
    +33 (0)157278022
  • Anaelle TAIEB, Ingénieure en biologie, CONDUIT LAB
    +33 (0)1 57 27 80 95, room 457B
  • Michiel Tawdarous, COLLIGNON LAB
  • Clémence THIANT, Doctorante, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 95, room 142B
  • Géraldine THOUVAY, Assistante de direction, DIRECTION
    +33 (0)1 57 27 81 42, room RB07B
  • Anne-Laure TODESCHINI, Enseignant-chercheur, VEITIA LAB
    +33 (0)1 57 27 81 17, room 526B
  • Sandra TOUATI, Chercheur, WASSMANN LAB
    +33 (0)1 57 27 80 35, room 322B
  • Teresa URLI, Doctorante, GREENBERG LAB
    +33 (0)1 57 27 81 20, room 542B
  • Nathalie VADROT, Ingénieure en biologie, DOYE LAB
    +33 (0)1 57 27 80 61, room 342B
  • Arthur VAISSADE, Ingénieur en biologie, AZIMZADEH LAB
    +33 (0)1 57 27 81 12, room 544B
  • Nicolas VALENTIN, Responsable cytométrie en flux, PFT/IMAGOSEINE/CYTOMETRIE
    +33 (0)1 57 27 81 52, room RH20B4
  • Lucie VAN HOVE, Assistante ingénieure en biologie, PINTARD LAB
    +33 (0)1 57 27 80 92, room 483B
  • Anne VANET, Enseignant-chercheur, DIRECTION
    +33 (0)1 57 27 59 63, room RB06B
  • Reiner VEITIA, Enseignant-chercheur, VEITIA LAB
    +33 (0)1 57 27 81 16, room 526B
  • Zoé VELASQUILLO RAMIREZ, Doctorante, GAZAVE LAB
    +33 (0)1 57 27 80 03, room 293B
  • Jean-Marc VERBAVATZ, Enseignant-chercheur, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 04, room 244B
  • Agathe VERRAES, Assistante-ingénieure en biologie, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 05, room 244B
  • Anais VERTUEUX, Doctorante, JACKSON/VERBAVATZ LAB
    +33 (0)1 57 27 80 05, room 244B
  • Hélène VIGNES, Postdoctorante, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 67, room 142B
  • Roshan Kumar VIJENDRAVARMA, Chercheur, COURTIER LAB
    +33 (0)1 57 27 80 83, room 416B
  • Marie VILLEMEUR, Ingénieure en biologie, RAOTE LAB
    +33 (0)1 57 27 81 45, room 285B
  • Marie VIRON, GUICHET LAB
    +33 (0)1 57 27 80 87, room 422B
  • Aurore VULLIEN, Doctorante, GAZAVE LAB
    +33 (0)1 57 27 81 01, room 293B
  • Katharina WASSMANN, Chercheur, WASSMANN LAB
    +33 (0)1 57 27 81 48, room 322B
  • Griselda WENTZINGER, Ingénieure en biologie, AZIMZADEH LAB
    +33 (0)1 57 27 81 12, room 544B
  • Michel WERNER, Collaborateur, DIRECTION
    +33 (0)1 57 27 81 38, room RB06B
  • Hugo WIOLAND, Chercheur, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Fanny WODRASCKA, Doctorante, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Lydie WONI MOUSSOUNDA, Responsable service Maintenance et Préparation du matériel biologique, SUPPORT/MILIEUX
    +33 (0)1 57 27 81 92, room 655B
  • Huiqiong WU, Postdoctorante, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Wang XI, Chercheur, LADOUX/MEGE LAB
    +33 (0)1 57 27 80 71, room 142B
  • Jiu XIAO, Doctorante, ROMET-LEMONNE/JEGOU LAB
    +33 (0)1 57 27 80 13, room 255B
  • Jiawei XU, MINC LAB
    +33 (0)157278052, room 316B
  • Zoubeir ZADVAT, Secrétaire général, DIRECTION
    +33 (0)1 57 27 81 38, room RB08B
  • Myriam ZHENG, Doctorante, PALANCADE LAB
    +33 (0)1 57 27 80 39, room 354B
  • Alain ZIDER, Enseignant-chercheur, VEITIA LAB
    +33 (0)1 57 27 80 85, room 526B

To contact a member of the team by e-mail: name.surname@ijm.fr

 

Selected Publications

Bouftas N.*, Schneider L.*, Halder M., Demmig R., Baack M., Cladière D., Walter M., Al Abdallah H., Kleinhempel C., Messaritaki R., Müller J., Passarelli F., Wehrle P., Heim A., Wassmann K.#+ and Mayer T.U.#

Cyclin-B3 prevents Emi2/Xerp1 from setting up precocious CSF-arrest in oocyte meiosis I,

Dev. Cell (2022) 57, 2305-2320

(*co first-authors, #co-corresponding authors, +lead author)

 

Nikalayevich E., El Jailani S., Cladière D., Gryaznova Y., Fosse C., Touati S.A., Buffin E., and Wassmann K.

Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes

Current Biology (2022) doi: 10.1016/j.cub.2022.03.041, in press

 

Gryaznova Y., Keating L.*, Touati S.A.*, Caldière D., El Yakoubi W., Buffin E., and Wassmann K.

Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II,

EMBO J. (2021) 40, e106797                         (*co second-authors)

 

Mehmet E. Karasu*, Bouftas N.*, Keeney S., and Wassmann K.

Cyclin B3 promotes anaphase I onset in oocyte meiosis,

J Cell Biol. (2019) 218, 1265-1281                            (*co first-authors)

 

Vallot A., Leontiou I., El Yakoubi W., Cladière D., Bolte S., Buffin E.*, and Wassmann K.*+

Tension-induced error correction, and not kinetochore attachment status activates the SAC in an Aurora-B/C-dependent manner in oocytes,

Current Biology (2018) 28, 130-139                            (*co-corresponding authors, + lead author )

 

El Yakoubi W., Buffin E., Cladière D, Gryaznova Y., Berenguer I., Touati S.A., Gómez R. , Suja J.A.,van Deursen J.M., and Wassmann, K.

Mps1 kinase-dependent Sgo2 centromere localization mediates cohesin protection in mouse oocyte meiosis I,

Nature Communications (2017) DOI: 10.1038/s41467-017-00774-3

 

Touati S., Buffin E., Cladière D., Rachez C., Hached K., van Deursen J.M., and Wassmann K.

Mouse oocytes depend on BubR1 for proper chromosome segregation but not prophase I arrest,

Nature Communications (2015) DOI: 10.1038/ncomms7946

 

Chambon J.P., Touati S., Berneau S., Cladière D., Hebras C., Groeme R., McDougall A., and Wassmann K.

The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in meiosis II,

Current Biology (2013) 23, 485-490

 

Touati S., Cladière D, Lister L.M., Leontiou I., Chambon J.P., Rattani A., Böttger F., Stemmann O., Nasmyth K., Herbert M., and Wassmann K.

Cyclin A2 is required for sister chromatid segregation, but not Separase control, in mouse oocyte meiosis,

Cell Reports (2012) 29, 1077-1087

 

Kudo N.R.*, Wassmann K.*, Anger M., Schuh M., Wirth G.K., Xu H., Helmhart W., Kudo H., Mckay M., Maro B., Ellenberg J., de Boer P., and Nasmyth K.

Resolution of Chiasmata in Oocytes Requires Separase-Mediated Proteolysis,

Cell (2006) 126, 135-146                               (*co first-authors)

 

Wassmann K.*, Niault T., and Maro B.

Metaphase I Arrest Upon Activation of the Mad2-Dependent Spindle Checkpoint in Mouse Oocytes

Curr. Biol. (2003) 13, 1596-1608                   (*corresponding author)

All the publications

Publications

Varela Salgado, M., Adriaans, I. E., Touati, S. A., Ibanes, S., Lai-Kee-Him, J., Ancelin, A., Cipelletti, L., Picas, L., & Piatti, S. (2024). Phosphorylation of the F-BAR protein Hof1 drives septin ring splitting in budding yeast. Nature Communications, 15(1), 3383. https://doi.org/10.1038/s41467-024-47709-3
Celebic, D., Polat, I., Legros, V., Chevreux, G., Wassmann, K., & Touati, S. A. (2024). Qualitative rather than quantitative phosphoregulation shapes the end of meiosis I in budding yeast. The EMBO Journal. https://doi.org/10.1038/s44318-024-00032-5
Dupré, A., & Wassmann, K. (2023). [Cyclin B3: Locking female meiosis to await fertilization]. Medecine Sciences: M/S, 39(3), 289–292. https://doi.org/10.1051/medsci/2023019
Nikalayevich, E., & Wassmann, K. (2022). Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor. STAR Protocols, 3(4), 101714. https://doi.org/10.1016/j.xpro.2022.101714
Wassmann, K. (2022). Separase Control and Cohesin Cleavage in Oocytes: Should I Stay or Should I Go? Cells, 11(21), 3399. https://doi.org/10.3390/cells11213399
Bouftas, N., Schneider, L., Halder, M., Demmig, R., Baack, M., Cladière, D., Walter, M., Al Abdallah, H., Kleinhempel, C., Messaritaki, R., Müller, J., Passarelli, F., Wehrle, P., Heim, A., Wassmann, K., & Mayer, T. U. (2022). Cyclin B3 implements timely vertebrate oocyte arrest for fertilization. Developmental Cell, 57(19), 2305-2320.e6. https://doi.org/10.1016/j.devcel.2022.09.005
Nikalayevich, E., El Jailani, S., Dupré, A., Cladière, D., Gryaznova, Y., Fosse, C., Buffin, E., Touati, S. A., & Wassmann, K. (2022). Aurora B/C-dependent phosphorylation promotes Rec8 cleavage in mammalian oocytes. Current Biology, 32(10), 2281-2290.e4. https://doi.org/10.1016/j.cub.2022.03.041
Gryaznova, Y., Keating, L., Touati, S. A., Cladière, D., El Yakoubi, W., Buffin, E., & Wassmann, K. (2021). Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis II. The EMBO Journal, 40(7), e106797. https://doi.org/10.15252/embj.2020106797
Lemonnier, T., Daldello, E. M., Poulhe, R., Le, T., Miot, M., Lignières, L., Jessus, C., & Dupré, A. (2021). The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division. Nature Communications, 12(1), 1837. https://doi.org/10.1038/s41467-021-22124-0
Jones, A. W., Flynn, H. R., Uhlmann, F., Snijders, A. P., & Touati, S. A. (2020). Assessing Budding Yeast Phosphoproteome Dynamics in a Time-Resolved Manner using TMT10plex Mass Tag Labeling. STAR Protocols, 1(1), 100022. https://doi.org/10.1016/j.xpro.2020.100022
Touati, S. A., Hofbauer, L., Jones, A. W., Snijders, A. P., Kelly, G., & Uhlmann, F. (2019). Cdc14 and PP2A Phosphatases Cooperate to Shape Phosphoproteome Dynamics during Mitotic Exit. Cell Reports, 29(7), 2105-2119.e4. https://doi.org/10.1016/j.celrep.2019.10.041
Touati, S. A., Kataria, M., Jones, A. W., Snijders, A. P., & Uhlmann, F. (2018). Phosphoproteome dynamics during mitotic exit in budding yeast. The EMBO Journal, 37(10), e98745. https://doi.org/10.15252/embj.201798745
Vallot, A., Leontiou, I., Cladière, D., El Yakoubi, W., Bolte, S., Buffin, E., & Wassmann, K. (2018). Tension-Induced Error Correction and Not Kinetochore Attachment Status Activates the SAC in an Aurora-B/C-Dependent Manner in Oocytes. Current Biology, 28(1), 130-139.e3. https://doi.org/10.1016/j.cub.2017.11.049
El Yakoubi, W., Buffin, E., Cladière, D., Gryaznova, Y., Berenguer, I., Touati, S. A., Gómez, R., Suja, J. A., van Deursen, J. M., & Wassmann, K. (2017). Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I. Nature Communications, 8(1), 694. https://doi.org/10.1038/s41467-017-00774-3
Lam, F., Cladière, D., Guillaume, C., Wassmann, K., & Bolte, S. (2017). Super-resolution for everybody: An image processing workflow to obtain high-resolution images with a standard confocal microscope. Methods, 115, 17–27. https://doi.org/10.1016/j.ymeth.2016.11.003
Godfrey, M., Touati, S. A., Kataria, M., Jones, A., Snijders, A. P., & Uhlmann, F. (2017). PP2ACdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation. Molecular Cell, 65(3), 393-402.e3. https://doi.org/10.1016/j.molcel.2016.12.018
Touati, S. A., Buffin, E., Cladière, D., Hached, K., Rachez, C., van Deursen, J. M., & Wassmann, K. (2015). Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nature Communications, 6(1), 6946. https://doi.org/10.1038/ncomms7946
Cyclin B3 promotes anaphase I onset in oocyte meiosis | Journal of Cell Biology | Rockefeller University Press. (n.d.). Retrieved April 5, 2024, from https://rupress.org/jcb/article/218/4/1265/61870/Cyclin-B3-promotes-anaphase-I-onset-in-oocyte

 

Reviews

Dupré, A., & Wassmann, K. (2023). La cycline B3, verrou de la méiose femelle en attendant la fécondation. médecine/sciences, 39(3), 289–292. https://doi.org/10.1051/medsci/2023019
Bouftas, N., & Wassmann, K. (2022). Working in close quarters: biparental meiosis in the oocyte. EMBO Reports, 23(7), e55360. https://doi.org/10.15252/embr.202255360
Lemonnier, T., Dupré, A., & Jessus, C. (2020). The G2-to-M transition from a phosphatase perspective: a new vision of the meiotic division. Cell Division, 15(1), 9. https://doi.org/10.1186/s13008-020-00065-2
Keating, L., Touati, S. A., & Wassmann, K. (2020). A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I. Cells, 9(2), 390. https://doi.org/10.3390/cells9020390
Bouftas, N., & Wassmann, K. (2019). Cycling through mammalian meiosis: B-type cyclins in oocytes. Cell Cycle, 18(14), 1537–1548. https://doi.org/10.1080/15384101.2019.1632139
Touati, S. A., & Uhlmann, F. (2018). A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit. Microbial Cell, 5(8), 389–392. https://doi.org/10.15698/mic2018.08.644
Marston, A. L., & Wassmann, K. (2017). Multiple Duties for Spindle Assembly Checkpoint Kinases in Meiosis. Frontiers in Cell and Developmental Biology, 5. https://doi.org/10.3389/fcell.2017.00109
El Yakoubi, W., & Wassmann, K. (2017). Meiotic Divisions: No Place for Gender Equality. In M. Gotta & P. Meraldi (Eds.), Cell Division Machinery and Disease (pp. 1–17). Springer International Publishing. https://doi.org/10.1007/978-3-319-57127-0_1
Touati, S. A., & Wassmann, K. (2016). How oocytes try to get it right: spindle checkpoint control in meiosis. Chromosoma, 125(2), 321–335. https://doi.org/10.1007/s00412-015-0536-7
Cells | Free Full-Text | Translational Control of Xenopus Oocyte Meiosis: Toward the Genomic Era. (n.d.). Retrieved April 5, 2024, from https://www.mdpi.com/2073-4409/9/6/1502

 

Book chapters

El Jailani, S., Wassmann, K., & Touati, S. A. (2024). Whole-Mount Immunofluorescence Staining to Visualize Cell Cycle Progression in Mouse Oocyte Meiosis. In A. Castro & B. Lacroix (Eds.), Cell Cycle Control: Methods and Protocols (pp. 211–227). Springer US. https://doi.org/10.1007/978-1-0716-3557-5_13
Nikalayevich, E., Bouftas, N., & Wassmann, K. (2018). Detection of Separase Activity Using a Cleavage Sensor in Live Mouse Oocytes. In M.-H. Verlhac & M.-E. Terret (Eds.), Mouse Oocyte Development: Methods and Protocols (pp. 99–112). Springer. https://doi.org/10.1007/978-1-4939-8603-3_11

Theses

Thesis defended:

  • Khaled Hached: 2006-2010
  • Sandra Touati: 2011- 2014
  • Antoine Vallot: 2014-2017
  • Nora Bouftas: 2015-2019
  •  Leonor Keating: 2017-2021

 

Thesis in progress:

  • Antoine Langeoire-Cassalta: 2019-
  • Dunja Čelebić: 2020-
  • Safia El Jailani: 2021-

Collaborations

Thomas Mayer, University of Konstanz, Germany

Evelyn Houliston, Laboratoire Océanologique de Villefranche-sur-Mer, France

GRANTS – FUNDING

Equipe FRM 2021-2024

ANR JCJC 2022-2025

ANR PRC 2019

News

04/07/2023 – Katja Wassmann, election as a member of the EMBO community

Job

We are recruiting an engineer (information to follow)