General information
Offer title : thèse en neurodéveloppment et oncologie (M/F) (H/F)
Reference : UMR7592-STENED-004
Number of position : 1
Workplace : PARIS 13
Date of publication : 14 August 2025
Type of Contract : FTC PhD student / Offer for thesis
Contract Period : 36 months
Start date of the thesis : 1 October 2025
Proportion of work : Full Time
Remuneration : 2200 gross monthly
Section(s) CN : 22 – Cellular biology, development, evolution-development, reproduction
Apply before Septembre 4th on the CNRS job portal
Description of the thesis topic
Diffuse midline gliomas (or DMGs) are incurable tumors associated with a median survival of less than one year and remain a major challenge in paediatric oncology. Their oncogenesis, linked to epigenetic dysregulation through histone H3 K27 alterations, is very specific in terms of anatomical location and associated with altered neurodevelopmental mechanisms. Our aim is to study in depth the heterogeneity and specificity of progenitors of the human hindbrain to better understand their susceptibility to this oncogenic process. The project integrates in the PEPR Cell-ID, which aims at understanding early lineage derail to identify possible strategies of cell-based disease interception.
Work Context
The person recruited will conduct a doctoral thesis under the joint supervision of Pascale Gilardi and David Castel, within the “Human Neurodevelopment and Diseases” team led by Vanessa Ribes and Stéphane Nedelec at the Jacques Monod Institute (https://www.ijm.fr/research-topics/ribes-nedelec-lab-va/?lang=en) and the “Genomics and oncogenesis of childhood brain tumors” team at the gustave roussy institute (https://www.gustaveroussy.fr/en/genomics-and-oncogenesis-childhood-brain-tumors)
The position is located in a sector under the protection of scientific and technical potential (PPST), and therefore requires, in accordance with the regulations, that your arrival is authorized by the competent authority of the MESR.
Constraints and risks
Work in L2 lab
possibility of shifts during weekends