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Human neurodevelopment and disorders

ERL 1340

Vanessa RIBES / Stéphane NEDELEC

Our team investigates the cellular and molecular mechanisms underlying human development and disease, including rhabdomyosarcoma, neural tube defects, spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS). To address these questions, we develop and employ organoid models derived from human and mouse pluripotent stem cells, in combination with studies in chick, mouse, and on human tissues.

Keywords: embryo, spinal cord, organoids, human and murine pluripotent stem cells, iPSC, development, signaling pathways, transcription factors, cell fates

 +33 (0)1 57 27 81 93   Contact Vanessa Ribes Contact Stéphane Nedelec