Septin remodelling in the control of cytokinesis in budding yeast
During cell division, chromosomes are faithfully duplicated and segregated, so that one copy of each chromosome can be inherited by the two daughter cells, which must carry identical genetic information. The fidelity of chromosome transmission has important medical implications. For example, aberrant chromosome numbers in eggs or sperms generate embryos that undergo spontaneous miscarriage or that have severe pathologies, such as the Down syndrome. Inaccurate genome partitioning during any of the millions of cell divisions taking place in our body can lead to tumour development.
Piatti’s lab studies the surveillance mechanisms that act during mitosis to ensure proper genome partitioning, using the budding yeast Saccharomyces cerevisiae as a model organism. Particularly, the research are focused on two aspects of mitosis that are crucial for preventing aneuploidy formation:
- How faithful chromosome segregation is overseen by the spindle assembly checkpoint (SAC) that monitors the correct attachment of chromosomes to the mitotic spindle;
- How mitotic exit and cytokinesis are regulated to preserve genome stability.