Institut Jacques Monod Seminar – Sumin Jang
5 May 2025 - 14 h 00 min - 15 h 00 min
Invited by the Ribes/Nedelec Lab, Sumin Jang (Department of Pathology and Cell biology, Columbia University, New York, USA) will present an Institut Jacques Monod seminar on the theme :
Human-specific progenitors extend and expand neurogenesis in the spinal cord
Her research explores the evolution of developmental programs and their implications for the increasing complexity of the human nervous system.
She combines single-cell omics with mouse and human organoids, to investigate these questions.
Selection of publications:
Independent control of neurogenesis and dorsoventral patterning by NKX2-2 Jang S, Abarinov E, Dobkin J, Wichterle H. bioRxiv [Preprint]. 2024 Oct 13:2024.10.13.618113. doi: 10.1101/2024.10.13.618113. PMID: 39415990 Free PMC article. Preprint
A human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production Jang S, Gumnit E, Wichterle H.Nat Neurosci. 2024 Oct;27(10):1945-1953. doi: 10.1038/s41593-024-01739-8. Epub 2024 Aug 29.PMID: 39210067
Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro. Patel T, Hammelman J, Aziz S, Jang S, Closser M, Michaels TL, Blum JA, Gifford DK, Wichterle H.Nat Commun. 2022 Sep 15;13(1):5427. doi: 10.1038/s41467-022-33022-4.PMID: 36109497Free PMC article.
An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity. Closser M, Guo Y, Wang P, Patel T, Jang S, Hammelman J, De Nooij JC, Kopunova R, Mazzoni EO, Ruan Y, Gifford DK, Wichterle H.Neuron. 2022 Jan 5;110(1):70-85.e6. doi: 10.1016/j.neuron.2021.10.014. Epub 2021 Nov 1.PMID: 34727520Free PMC article.