Le mardi 20 juin 2023, les conférences Monod-Diderot accueillent en salle François Jacob, Judith Frydman – (Department of Genetics and Biology at Stanford University) qui interviendra sur le thème :
Molecular Origami: The TRiCky business of folding proteins in the cell
The eukaryotic chaperonin TRiC/CCT is a large hetero-oligomeric complex that plays an essential role assisting cellular protein folding and suppressing protein aggregation. It consists of two rings, each composed of eight different subunits; non-native polypeptides bind and fold in an ATP-dependent manner within their central chamber. I will discuss recent advances in our understanding of TRiC structure and mechanism which reveal how the different TRiC/CCT subunits create asymmetry in its ATP-driven conformational cycle and its interaction with non-native polypeptides, which ultimately underlie its unique ability to fold proteins that cannot be folded by other chaperones.