L'équipe Palancade a publié une nouvelle review dans Current Opinion in Genetics & Development : On the edge: how nuclear pore complexes rule genome stability   Résumé : Nuclear organization has emerged as a critical layer in the coordination of DNA repair activities. Distinct types of DNA lesions have notably been shown to relocate at the vicinity…

L'équipe Greenberg a contribué à la publication d'un nouvel article dans Nature Structural & Molecular biology : DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation   Résumé : As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation levels. During this transition, the…

L'équipe Camadro et la plateforme ProtéoSeine ont contribué à la publication d'un nouvel article dans eBioMedicine : Multiomic analysis in fibroblasts of patients with inborn errors of cobalamin metabolism reveals concordance with clinical and metabolic variability   Résumé : Background The high variability in clinical and metabolic presentations of inborn errors of cobalamin (cbl) metabolism (IECM), such as the cblC/epicblC types…

L'équipe Raote a contribué à la publication d'un nouvel article dans PNAS : A model for collagen secretion by intercompartmental continuities   Résumé : Newly synthesized secretory proteins are exported from the endoplasmic reticulum (ER) at specialized subcompartments called exit sites (ERES). Cargoes like procollagen are too large for export by the standard COPII-coated vesicle of 60 nm…

L'équipe Balavoine a récemment publié un nouvel article dans Plos One : Fast cycling culture of the annelid model Platynereis dumerilii   Résumé : Platynereis dumerilii, a marine annelid, is a model animal that has gained popularity in various fields such as developmental biology, biological rhythms, nervous system organization and physiology, behaviour, reproductive biology, and epigenetic regulation. The…