L'équipe Palancade a contribué à la publication d'un nouvel article dans Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Résumé : Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these…

L'équipe Greenberg a publié un nouvel article dans Nature structural & molecular biology : The impact of DNA methylation on CTCF-mediated 3D genome organization Résumé Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of…

Les plateformes ProtéoSeine et ImagoSeine ont contribué à la publication d'un article dans Nature communications : Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Résumé Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved…

L'équipe Gazave a publié un nouvel article dans Scientific report : Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona Résumé Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis…