L'équipe Ladoux/Mège publie un nouvel article dans Biomaterials   Bioengineering a miniaturized in vitro 3D myotube contraction monitoring chip to model muscular dystrophies   Abstract Quantification of skeletal muscle functional contraction is essential to assess the outcomes of therapeutic procedures for neuromuscular disorders. Muscle three-dimensional “Organ-on-chip” models usually require a substantial amount of biological material, which rarely…

L'équipe Vervoort vient de publier un nouvel article dans JEZ-B: Molecular and Developmental Evolution : On the hormonal control of posterior regeneration in the annelid Platynereis dumerilii   Abstract Regeneration is the process by which many animals are able to restore lost or injured body parts. After amputation of the posterior part of its body, the annelid Platynereis dumerilii is…

L'équipe Ladoux/Mège vient de publier un article dans Nature Physics :   Mechanical stress driven by rigidity sensing governs epithelial stability Abstract: Epithelia act as barriers against environmental stresses. They are continuously exposed to various mechanical stress and abrasion, which impact epithelial integrity. The impact of the environment on epithelial integrity remains elusive. By culturing epithelial cells…

L'équipe Minc vient de publier une nouvelle revue dans Journal of Cell Science : Mechanobiology of the cell wall – insights from tip-growing plant and fungal cells ABSTRACT The cell wall (CW) is a thin and rigid layer encasing the membrane of all plant and fungal cells. It ensures mechanical integrity by bearing mechanical stresses derived…

L'équipe Veitia vient de publier un nouvel article dans Clinical Genetics :   Recurrent missense variants in clonal hematopoiesis-related genes present in the general population   Abstract Clonal hematopoiesis (CH) consists in an abnormal expansion of a hematopoietic stem cell bearing an advantageous somatic variant. A survey of known recurrent somatic missense variants in DNMT3A, SF3B1, SRSF2 and TP53, some of the…

Un nouvel article publié dans Cancers : Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death Abstract Auranofin (Ridaura®, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR). However,…

L'équipe Wassmann vient de publier un nouvel article dans Developmental Cell: Cyclin B3 implements timely vertebrate oocyte arrest for fertilization Summary To ensure successful offspring ploidy, vertebrate oocytes must halt the cell cycle in meiosis II until sperm entry. Emi2 is essential to keep oocytes arrested until fertilization. However, how this arrest is implemented exclusively in…

L'équipe Wassmann vient de publier un nouvel article dans Star Protocols! Protocol to measure cleavage efficiency of the meiotic cohesin subunit Rec8 by separase in mouse oocytes using a biosensor Summary Here, we describe a biosensor to assess meiotic cohesin subunit Rec8 cleavage in mouse oocytes. We detail oocyte collection and microinjection of the mRNA expressing…

L'équipe Ladoux/Mège vient de publier un nouvel article dans Science Advances : The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces   Abstract Three-dimensional collective epithelial rotation around a given axis represents a coordinated cellular movement driving tissue morphogenesis and transformation. Questions regarding these behaviors and their relationship with substrate curvatures are intimately linked to spontaneous…

L'équipe Plessis vient de publier dans eLife un nouvel article : High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened Abstract The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial…