The Palancade Lab contributed to the publication of a new article in Nature communications : Accelerated DNA replication fork speed due to loss of R-loops in myelodysplastic syndromes with SF3B1 mutation Abstract: Myelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences…

The Greenberg Lab published a new article in Nature structural & molecular biology: The impact of DNA methylation on CTCF-mediated 3D genome organization Abstract: Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although the role of DNA methylation at gene promoters and repetitive elements has been extensively studied, the function of DNA methylation…

The ProtéoSeine et ImagoSeine plateforms contributed to the publication of an article in Nature communications: Theileria parasites sequester host eIF5A to escape elimination by host-mediated autophagy Abstract Intracellular pathogens develop elaborate mechanisms to survive within the hostile environments of host cells. Theileria parasites infect bovine leukocytes and cause devastating diseases in cattle in developing countries. Theileria spp. have evolved sophisticated strategies…

The Gazave Lab published a new article in Scientific report: Extrinsic apoptosis participates to tail regression during the metamorphosis of the chordate Ciona Abstract: Apoptosis is a regulated cell death ubiquitous in animals defined by morphological features depending on caspases. Two regulation pathways are described, currently named the intrinsic and the extrinsic apoptosis. While intrinsic apoptosis is…