L'équipe Ribes a publié un nouvel article dans Emerging topics in life sciences : Stem cell-derived models of spinal neurulation   Résumé : This review is the fruit of an enriching collaboration with my thesis supervisors Vanessa Ribes and Stéphane Nedelec (Institut du Fer à Moulin), along with Martin Catala (Institut de Biologie Paris Seine) and Mikaëlle Bocel…

L'équipe Courtier a récemment publié un nouvel article dans Plos one : Recommended distances for physical distancing during COVID-19 pandemics reveal cultural connections between countries   Résumé : During COVID-19 pandemic several public health measures were implemented by diverse countries to reduce the risk of COVID-19, including social distancing. Here we collected the minimal distance recommended by each…

L'équipe Léon a contribué à la publication d'un article dans Molecular Cell : Ubiquiton - An inducible, linkage-specific polyubiquitylation tool   Résumé : The posttranslational modifier ubiquitin regulates most cellular processes. Its ability to form polymeric chains of distinct linkages is key to its diverse functionality. Yet, we still lack the experimental tools to induce linkage-specific polyubiquitylation of…

L'équipe Camadro a publié un nouvel article dans NAR Genomics & Bioinformatics : 3D models of fungal chromosomes to enhance visual integration of omics data   Résumé : The functions of eukaryotic chromosomes and their spatial architecture in the nucleus are reciprocally dependent. Hi-C experiments are routinely used to study chromosome 3D organization by probing chromatin interactions. Standard…

L'équipe Borghi a récemment contribué à la publication d'un article dans Experimental Hematology & Oncology : ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells   Résumé : Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in…

L'équipe Collignon a récemment publié un nouvel article dans Non-coding RNA : LADON , a Natural Antisense Transcript of NODAL , Promotes Tumour Progression and Metastasis in Melanoma   Résumé : The TGFβ family member NODAL, repeatedly required during embryonic development, has also been associated with tumour progression. Our aim was to clarify the controversy surrounding its involvement in…

L'équipe Minc a récemment publié un nouvel article dans Cell Dynamics : Cytoplasm mechanics and cellular organization   Résumé : As cells organize spatially or divide, they translocate many micron-scale organelles in their cytoplasm. These include endomembrane vesicles, nuclei, microtubule asters, mitotic spindles, or chromosomes. Organelle motion is powered by cytoskeleton forces but is opposed by viscoelastic forces imparted by…

L'équipe Cadoret a contribué a la publication d'un article dans EMBO reports : The nucleolar protein GNL3 prevents resection of stalled replication forks   Résumé : Faithful DNA replication requires specific proteins that protect replication forks and so prevent the formation of DNA lesions that may damage the genome. Identification of new proteins involved in this process is…

L'équipe Konstantinides a publié un nouvel article dans The FEBS Journal : Evolution of patterning   Résumé : Developing tissues are patterned in space and time; this enables them to differentiate their cell types and form complex structures to support different body plans. Although space and time are two independent entities, there are many examples of spatial patterns…

Le domaine forkhead de liaison à l’ADN reconnait également une séquence d’ARN riche en GG.   Cette étude, publiée dans Nucleic Acids Research, résulte d’une collaboration entre les équipes de Reiner A. Veitia (directeur de l’Institut de Biologie Francois Jacob et Professeur à l’Université Paris Cité) et l’équipe de Frédéric Ducongé (CEA-MIRCen, UMR CNRS 9199, Université…