Conduit Lab – Building the centrosome: PLK-1 controls multimerization of SPD-5

The Conduit Lab published a spotlight in Journal of Cell Biology:

Building the centrosome: PLK-1 controls multimerization of SPD-5

Introduction:

Centrosome maturation relies on the assembly of an underlying molecular scaffold. In this issue of JCB, Rios et al. (https://doi.org/10.1083/jcb.202306142) use cross-linking mass spectrometry to reveal how PLK-1 phosphorylation promotes intermolecular SPD-5 self-association that is essential for scaffold formation.