L'équipe Veitia a publié un nouvel article dans Trends in Genetics : Emerging links between phase separation and transcription factor haploinsufficiency   Résumé : Recent studies have addressed the relevance of phase separation, by which membrane-less compartments are formed within the nucleus, to understand the impact of genetic variants. They highlight unsuspected links between phase separation and haploinsufficiency…

L'équipe Greenberg a publié un nouvel article dans Nature structural & Molecular biology: DNA methylation shapes the Polycomb landscape during the exit from naive pluripotency Résumé : In mammals, 5-methylcytosine (5mC) and Polycomb repressive complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit…

L'équipe Grange / Geigl a publié un nouvel article dans Molecular biology and evolution : The Population History of Domestic Sheep Revealed by Paleogenomes   Résumé : Sheep was one of the first domesticated animals in Neolithic West Eurasia. The zooarchaeological record suggests that domestication first took place in Southwest Asia, although much remains unresolved about the precise…

L'équipe Ribes a publié un nouvel article dans Elife: BMP2 and BMP7 cooperate with H3.3K27M to promote quiescence and invasiveness in pediatric diffuse midline gliomas   Résumé : Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably with the identification of K27M mutations…

L'équipe Prioleau a publié un nouvel article dans Nucleic Acids Research : DciA secures bidirectional replication initiation in Vibrio cholerae   Résumé : Replication is initiated bidirectionally in the three domains of life by the assembly of two replication forks at an origin of replication. This is made possible by the recruitment of two replicative helicases to a nucleoprotein…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Molecular Cell : Cell-cycle-dependent mRNA localization in P-bodies   Résumé : Understanding the dynamics of RNA targeting to membraneless organelles is essential to disentangle their functions. Here, we investigate how P-bodies (PBs) evolve during cell-cycle progression in HEK293 cells. PB purification across the cell cycle…

L'équipe Courtier a publié un nouvel article dans Scientific Reports : Adhesive and mechanical properties of the glue produced by 25 Drosophila species   Résumé : Drosophila glue, a bioadhesive produced by fly larvae to attach themselves to a substrate for several days, has recently gained attention for its peculiar adhesive and mechanical properties. Although Drosophila glue production was described more than 50 years…

L'équipe Dumont a publié un nouvel article dans Current Biology : Regulation of outer kinetochore assembly during meiosis I and II by CENP-A and KNL-2/M18BP1 in C. elegans oocytes   Résumé : During cell division, chromosomes build kinetochores that attach to spindle microtubules. Kinetochores usually form at the centromeres, which contain CENP-A nucleosomes. The outer kinetochore, which is the core…

L'équipe Pintard a contribué à la publication d'un nouvel article dans Nucleic Acids Research : Enhanced Golden Gate Assembly: evaluating overhang strength for improved ligation efficiency   Résumé : Molecular cloning, a routine yet essential technique, relies heavily on efficient ligation, which can be significantly improved using Golden Gate Assembly (GGA). A key component of GGA is the use…

L'équipe Gazave a publié un nouvel article dans Genome Biology and Evolution : Evolution of apoptotic signalling pathways within lophotrochozoans   Résumé : Apoptosis is the main form of regulated cell death in metazoans. Apoptotic pathways are well characterised in nematode, fly and mammals, leading to a vision of the conservation of apoptotic pathways in metazoans. However, we…