L'équipe Romet-Lemonne/Jégou a publié une nouvelle publication dans PNAS : Continuous self-repair protects vimentin intermediate filaments from fragmentation Résumé : Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved in migration, forms a dense network in the cytoplasm that is constantly remodeling through filament transport, elongation/shortening,…

L'équipe Ladoux/Mège a contribué à la publication d'un nouvel article dans The European Physical Journal E : Osmotic pressure induces unexpected relaxation of contractile 3D microtissue   Résumé : Cell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects…

L'équipe Minc a publié un nouvel article dans Current Biology : Cell division: Size-scaling cytoplasmic flows transport chromosomes to the right spot   Résumé : Early embryos undergo rounds of division, producing cells of reducing sizes that must scale the distance chromosomes segregate. A new study shows that this scaling results from a cell-size-dependent dampening of cytoplasmic flows…

L'équipe Minc a publié un nouvel article dans Journal of the royal society interface : Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays Résumé : We used numerical simulations to investigate how properties of motor proteins control the dynamical behaviour of driven flexible filaments. A filament on top of a patch of anchored motor proteins…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans Rapid Communications in Mass Spectometry : Electron Transfer Dissociation and Synchrotron UV Photodissociation of Trapped Sodiated Ions Produced From Polyacrylates by Electrospray Ionization   Résumé : Rationale Poly (acrylates)s can be distinguished from one another by the nature of their side chains. From model poly (acrylates)s, the…

L'équipe Ladoux/Mege a publié un nouvel article dans PNAS : Flocking and giant fluctuations in epithelial active solids Significance During embryonic development and wound healing, epithelial cells usually display in-plane polarity over large spatial scales and move coherently. However, most in vitro studies have examined the fluid-like chaotic dynamics of epithelial cells, in which collective cellular flows…

L'équipe Wassmann a publié un nouvel article dans Current Biology : Prolonged metaphase II arrest weakens Aurora B/C-dependent error correction in mouse oocytes   Résumé : Segregation errors in meiosis lead to aneuploid gametes and consequently to the development of trisomies, spontaneous abortion and fertility issues. Chromosome attachment to the microtubules of the bipolar spindle is a…

L'équipe Doye a contribué à la publication d'un nouvel article dans Nature cell biology : Nuclear pores safeguard the integrity of the nuclear envelope   Résumé : Nuclear pore complexes (NPCs) mediate nucleocytoplasmic exchange, which is essential for eukaryotes. Mutations in the central scaffolding components of NPCs are associated with genetic diseases, but how they manifest only in specific…

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Nature Communications : A differential requirement for ciliary transition zone proteins in human and mouse neural progenitor fate specification   Résumé : Studying ciliary genes in the context of the human central nervous system is crucial for understanding the underlying causes of neurodevelopmental ciliopathies. Here, we use…