L'équipe Veitia a récemment publié un nouvel article dans Bio Essays : Dominant negative variants and cotranslational assembly of macromolecular complexes Résumé : Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency.…

L'équipe Palancade a récemment publié un nouvel article dans FEBS Letters : Puzzling out nuclear pore complex assembly Résumé :  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes…

L'équipe Dumont a publié un article dans Current Biology : An unconventional TOG domain is required for CLASP localization Résumé : Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene…

L'équipe Greenberg a récemment contribué à la publication d'un nouvel article dans Nature Structural & Molecular Biology : A genome-wide screen reveals new regulators of the 2-cell-like cell state Résumé : In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear…

L'équipe Pintard a récemment publié dans Science Advances : Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Résumé : The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during…

L'équipe Cadoret a récemment publié un article dans International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Résumé : Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F…

L'équipe Minc a récemment publié un nouvel article dans Developmental Cell : Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Résumé : Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to…

La plateforme ProtéoSeine a contribué à la publication d'un nouvel article dans  Journal of Cellular and Molecular Medicine : Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice Résumé : Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate…

L'équipe Dumont a récemment publié dans Nature Communications : Kinetochore component function in C. elegans oocytes revealed by 4D tracking of holocentric chromosomes Résumé : During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite…

L'équipe Raote a contribué à la publication d'une nouvelle revue dans Disease Models & Mechanisms : CYLD in health and disease Résumé : CYLD lysine 63 deubiquitinase (CYLD) is a ubiquitin hydrolase with important roles in immunity and cancer. Complete CYLD ablation, truncation and expression of alternate isoforms, including short CYLD, drive distinct phenotypes and offer insights into CYLD…