L'équipe Prioleau a contribué à la publication d'un nouvel article dans Nature communications : Histone H3 serine-57 is a CHK1 substrate whose phosphorylation affects DNA repair Résumé : Histone post-translational modifications promote a chromatin environment that controls transcription, DNA replication and repair, but surprisingly few phosphorylations have been documented. We report the discovery of histone H3 serine-57…

L'équipe Palancade a contribué à la publication d'un nouvel article dans Plos Genetics : Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import Résumé : N-terminal ends of polypeptides are critical for the selective co-translational recruitment of N-terminal modification enzymes. However, it is unknown whether specific N-terminal signatures differentially regulate protein fate…

L'équipe Prioleau a récemment publié un nouvel article dans Nature Communications : Dimeric G-quadruplex motifs-induced NFRs determine strong replication origins in vertebrates Résumé : Replication of vertebrate genomes is tightly regulated to ensure accurate duplication, but our understanding of the interplay between genetic and epigenetic factors in this regulation remains incomplete. Here, we investigated the involvement of three…

L'équipe Veitia a récemment publié un nouvel article dans Bio Essays : Dominant negative variants and cotranslational assembly of macromolecular complexes Résumé : Pathogenic variants occurring in protein-coding regions underlie human genetic disease through various mechanisms. They can lead to a loss of function (LOF) such as in recessive conditions or in dominant conditions due to haploinsufficiency.…

L'équipe Palancade a récemment publié un nouvel article dans FEBS Letters : Puzzling out nuclear pore complex assembly Résumé :  Nuclear pore complexes (NPCs) are sophisticated multiprotein assemblies embedded within the nuclear envelope and controlling the exchanges of molecules between the cytoplasm and the nucleus. In this review, we summarize the mechanisms by which these elaborate complexes…

L'équipe Dumont a publié un article dans Current Biology : An unconventional TOG domain is required for CLASP localization Résumé : Cytoplasmic linker-associated proteins (CLASPs) form a conserved family of microtubule-associated proteins (MAPs) that maintain microtubules in a growing state by promoting rescue while suppressing catastrophe.1  CLASP function involves an ordered array of tumor overexpressed gene…

L'équipe Greenberg a récemment contribué à la publication d'un nouvel article dans Nature Structural & Molecular Biology : A genome-wide screen reveals new regulators of the 2-cell-like cell state Résumé : In mammals, only the zygote and blastomeres of the early embryo are totipotent. This totipotency is mirrored in vitro by mouse ‘2-cell-like cells’ (2CLCs), which appear…

L'équipe Pintard a récemment publié dans Science Advances : Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos Résumé : The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during…

L'équipe Cadoret a récemment publié un article dans International Journal of Molecular Sciences : Firing of Replication Origins Is Disturbed by a CDK4/6 Inhibitor in a pRb-Independent Manner Résumé : Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F…

L'équipe Minc a récemment publié un nouvel article dans Developmental Cell : Length limitation of astral microtubules orients cell divisions in murine intestinal crypts Résumé : Planar spindle orientation is critical for epithelial tissue organization and is generally instructed by the long cell-shape axis or cortical polarity domains. We introduced mouse intestinal organoids in order to…