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Wassmann Lab – Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II

L'équipe Wassmann a publié un nouvel article dans EMBO : Eliminating separase inhibition reveals absence of robust cohesin protection in oocyte metaphase II Abstract : The meiotic segregation pattern to generate haploid gametes is mediated by step-wise cohesion removal by separase, first from chromosome arms in meiosis I, and then from the pericentromere in meiosis II. In…

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Minc Lab – Inferring diffusion, reaction, and exchange parameters from imperfect FRAP

L'équipe Minc a contribué à la publication d'un nouvel article dans Biophysical Journal : Inferring diffusion, reaction, and exchange parameters from imperfect FRAP Résumé : Fluorescence recovery after photobleaching (FRAP) is broadly used to investigate the dynamics of molecules in cells and tissues, notably to quantify diffusion coefficients. FRAP is based on the spatiotemporal imaging of fluorescent…

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Hommage à Clarisse Orniacki

C’est avec une infinie tristesse que nous avons appris le décès de Clarisse Orniacki. Etudiante du magistère de génétique, Clarisse avait rejoint l'équipe "Fonctions non-conventionnelles des pores nucléaires"comme doctorante et avait brillamment soutenu sa thèse en décembre 2022. C’était une jeune femme pleine de vie, motivée, déterminée, brillante, engagée, mais aussi douce et discrète, avec devant…

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Ribes/Nedelec Lab – GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration

L'équipe Ribes/Nedelec a contribué à la publication d'un nouvel article dans Science Advances : GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration   Résumé : The saltatory migration of neurons is essential for brain formation. Whether mechanical stimuli regulate this process is unknown. Here, we show that the primary cilium acts as a mechanical sensor through…

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Wassmann Lab – “JessTM Simple WesternTM”: A New Technology to Assess Protein Abundance in Mouse Oocytes

L'équipe Wassmann a contribué à l'ouvrage Mammalian Oocyte Development : “JessTM Simple WesternTM”: A New Technology to Assess Protein Abundance in Mouse Oocytes Résumé : Traditional Western blot technology coupled with two-dimensional  SDS-PAGE has been used for decades to detect specific proteins in extracts. Here we describe an automated Western technology based on protein separation by capillary assay.…

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Jackson/Verbavatz – Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases

L'équipe Jackson/Verbavatz a contribué à la publication d'un nouvel article dans Traffic : Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases Résumé : Arf and Rab family small GTPases and their regulators, GTPase-activating proteins (GAPs) and guanine nucleotide exchange factors (GEFs), play a central role in membrane trafficking. In this study, we…

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Gazave Lab – A genome resource for the marine annelid Platynereis spp

L'équipe Gazave a contribué à la publication d'un nouvel article dans BMC Genomics : A genome resource for the marine annelid Platynereis spp Résumé : The marine annelid Platynereis dumerilii is a model organism used in many research areas including evolution and development, neurobiology, ecology and regeneration. Here we present the genomes of P. dumerilii (laboratory culture…

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Romet-Lemonne/Jégou Lab – La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires

L'équipe Romet-Lemonne/Jégou a contribué à la publication d'un nouvel article dans médecine/science : La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires Lemichez E, Morel C, Leduc C, Bassereau P. La cavéoline-1 rigidifie la membrane plasmique et limite l’expansion de tunnels transcellulaires [Caveolin-1 stiffens the plasma membrane and limits transcellular tunnel expansion]. Med…

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Ladoux/Mege Lab – A multicellular star-shaped actin network underpins epithelial organization and connectivity

L'équipe Ladoux/Mege a contribué à la publication d'un nouvel article dans Nature Communications : A multicellular star-shaped actin network underpins epithelial organization and connectivity Résumé : Epithelial tissues withstand external stresses while maintaining structural stability. Bicellular junctions and the actomyosin network support epithelial integrity, packing and remodelling. While their role in development and disease are well studied,…

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